IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

Stable Identifier
R-HSA-1855207
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5).

The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008).

Literature References
PubMed ID Title Journal Year
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH

J Biol Chem 2001
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Draskovic, P, Saiardi, A, Bhandari, R, Burton, A, Ilc, G, Kovacevic, M, Snyder, SH, Podobnik, M

Chem Biol 2008
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD

Science 2007
Participants
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Catalyst Activity
Title
inositol hexakisphosphate kinase activity of IP6K1/2 [nucleoplasm]
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Rhea
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