I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

Stable Identifier
R-HSA-1855213
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.

Literature References
PubMed ID Title Journal Year
7721860 Properties of type II inositol polyphosphate 5-phosphatase

Jefferson, AB, Majerus, PW

J Biol Chem 1995
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Schmid, AC, Wise, HM, Mitchell, CA, Nussbaum, R, Woscholski, R

FEBS Lett 2004
1718960 Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase

Ross, TS, Jefferson, AB, Mitchell, CA, Majerus, PW

J Biol Chem 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of Inositol polyphosphate 5-phosphatase [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created