IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen

Stable Identifier
R-HSA-1855225
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the endoplasmic reticulum (ER) lumen, multiple inositol polyphosphate phosphatase 1 (MINPP1) dephosphorylates 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 1,2,4,5,6-pentakisphosphate (I(1,2,4,5,6)P5) (Caffrey et al. 1999, Chi et al. 1999, Deleu et al. 2006, Nogimori et al. 1991).

Literature References
PubMed ID Title Journal Year
1653239 Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity

Nogimori, K, Hughes, PJ, Glennon, MC, Hodgson, ME, Putney JW, Jr, Shears, SB

J Biol Chem 1991
10087200 Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19

Chi, H, Tiller, GE, Dasouki, MJ, Romano, PR, Wang, J, O'keefe, RJ, Puzas, JE, Rosier, RN, Reynolds, PR

Genomics 1999
9923613 The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification

Caffrey, JJ, Hidaka, K, Matsuda, M, Hirata, M, Shears, SB

FEBS Lett 1999
15979280 Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool

Deleu, S, Choi, K, Pesesse, X, Cho, J, Sulis, ML, Parsons, R, Shears, SB

Cell Signal 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol hexakisphosphate 2-phosphatase activity of MINPP1 [endoplasmic reticulum lumen]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created