IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol

Stable Identifier
R-HSA-1855227
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5).

The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008; Lin et al. 2009) and IP6K3 (Saiardi et al. 2001, Draskovic et al. 2008).

Literature References
PubMed ID Title Journal Year
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Draskovic, P, Saiardi, A, Bhandari, R, Burton, A, Ilc, G, Kovacevic, M, Snyder, SH, Podobnik, M

Chem Biol 2008
18981179 Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases

Lin, H, Fridy, PC, Ribeiro, AA, Choi, JH, Barma, DK, Vogel, G, Falck, JR, Shears, SB, York, JD, Mayr, GW

J Biol Chem 2009
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH

J Biol Chem 2001
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD

Science 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol hexakisphosphate kinase activity of IP6K1/3 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created