I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

Stable Identifier
R-HSA-1855228
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, inositol polyphosphate multikinase (IPMK) phosphorylates inositol 1,3,4,6-tetrakisphosphate (I(1,3,4,6)P4) to inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) (Chang et al. 2002, Chang & Majerus 2006).

Literature References
PubMed ID Title Journal Year
12223481 The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase

Chang, SC, Miller, AL, Feng, Y, Wente, SR, Majerus, PW

J Biol Chem 2002
16293229 Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate

Chang, SC, Majerus, PW

Biochem Biophys Res Commun 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol tetrakisphosphate 5-kinase activity of IPMK [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created