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p-6Y-SYK [cytosol]
Stable Identifier
R-HSA-1861712
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase SYK , Spleen tyrosine kinase
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
IgG:Leishmania surface:p-FCGR3As:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Recruitment of PLCgamma to membrane due to FCGR3A effect (Homo sapiens)
IgG:Leishmania surface:p-FCGR3As:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Release of PLCG from FCGR3A (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
BTK autophosphorylates (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
SYK autophosphorylates at the activated BCR (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-SYK and LYN phosphorylate BTK (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
LYN, p-SYK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
Dectin-2 family (Homo sapiens)
PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
SYK/LCK/ZAP-70 [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
SYK/LCK/ZAP-70 [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
SYK/LCK/ZAP-70 [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-SYK,p-BTK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
SYK/LCK/ZAP-70 [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
SYK/BTK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation of SHC by SYK kinase (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
SYK/FYN [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
FCGR activation (Homo sapiens)
Phosphorylation of SYK by Src kinases (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation of VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
PI3K binds to p-6Y-SYK (Homo sapiens)
PI3K:p-6Y-SYK [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K:p-6Y-SYK [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Phosphorylation and activation of PLCG (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Recruitment of PLCgamma to membrane (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
Release of PLCG from FCGR (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
p-6Y-SYK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43405 SYK
Gene Names
SYK
Chain
chain:1-635
Reference Genes
COSMIC (genes):SYK P434052
dbSNP Gene:6850 P434052
ENSEMBL:ENSG00000165025 SYK
Participates
as a member of
SYK/BTK [cytosol] (Homo sapiens)
p-SYK,p-BTK [cytosol] (Homo sapiens)
SYK/LCK/ZAP-70 [cytosol] (Homo sapiens)
as a component of
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y-SYK [cytosol]
p-Y-SYK [plasma membrane]
SYK [plasma membrane]
p-Y348-SYK [cytosol]
SYK [cytosol]
Inferred To
phospho-SYK [cytosol]
(Bos taurus)
phospho-SYK [cytosol]
(Canis familiaris)
phospho-p-6Y-SYK [cytosol]
(Drosophila melanogaster)
phospho-p-6Y-SYK [cytosol]
(Gallus gallus)
phospho-p-6Y-SYK [cytosol]
(Mus musculus)
phospho-p-6Y-SYK [cytosol]
(Rattus norvegicus)
phospho-p-6Y-SYK [cytosol]
(Sus scrofa)
phospho-p-6Y-SYK [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 348
Coordinate
348
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 352
Coordinate
352
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 525
Coordinate
525
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 526
Coordinate
526
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 131
Coordinate
131
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 323
Coordinate
323
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.873
10
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.831
8
UniProt:P06239 LCK
4
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
0.748
8
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.743
7
UniProt:P36888 FLT3
20
FLT3 F691I [plasma membrane]
(R-HSA-9702900)
FLT3 N676D [plasma membrane]
(R-HSA-9702895)
FLT3 R834Q [plasma membrane]
(R-HSA-9691899)
FLT3 Y572C [plasma membrane]
(R-HSA-9691902)
FLT3 A848P [plasma membrane]
(R-HSA-9702909)
FLT3 A627P [plasma membrane]
(R-HSA-9699448)
FLT3 F621L [plasma membrane]
(R-HSA-9699426)
p-Y768,Y969 FLT3 [plasma membrane]
(R-HSA-9698405)
Ub-pY FLT3 [endosome membrane]
(R-HSA-9706174)
Ub-pY FLT3 [plasma membrane]
(R-HSA-9706171)
FLT3 V592G [plasma membrane]
(R-HSA-9691071)
FLT3 F590_F605dup [plasma membrane]
(R-HSA-9697939)
FLT3 F590G Y591D [plasma membrane]
(R-HSA-9691062)
FLT3 F594L [plasma membrane]
(R-HSA-9691058)
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
(R-HSA-9699433)
FLT3 V579A [plasma membrane]
(R-HSA-9691051)
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
(R-HSA-9696044)
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
(R-HSA-9696043)
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
(R-HSA-9690076)
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
(R-HSA-9696033)
0.737
22
UniProt:P20273 CD22
3
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
CD22 [plasma membrane]
(R-HSA-197703)
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
0.623
4
UniProt:P07766 CD3E
2
p-Y188,Y199-CD3E [plasma membrane]
(R-HSA-202228)
CD3E [plasma membrane]
(R-HSA-197906)
0.597
6
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.591
4
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.581
5
UniProt:Q96IP4 TET5A
0.57
3
UniProt:P30273 FCER1G
5
FCER1G [tertiary granule membrane]
(R-HSA-6800183)
FCER1G [ficolin-1-rich granule membrane]
(R-HSA-6801016)
p-Y65-FCER1G [plasma membrane]
(R-HSA-2454244)
FCER1G [plasma membrane]
(R-HSA-54715)
p-Y65,Y76-FCER1G [plasma membrane]
(R-HSA-141096)
0.564
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.556
3
UniProt:Q8TF42 UBS3B
0.544
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
ChEBI:39112 BOSUTINIB
0.499
2
UniProt:P11049 CD37
0.499
3
ChEBI:49375 DASATINIB
0.499
2
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.462
4
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.462
3
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