Reactome | IAPP(1-89) [cytosol]

IAPP(1-89) [cytosol]

Stable Identifier

R-HSA-186631

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IAPP, Islet amyloid polypeptide, Amylin

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External Reference Information

External Reference

UniProt:P10997 IAPP

Gene Names

IAPP

Chain

signal peptide:1-22, propeptide:23-31, peptide:34-70, propeptide:74-89

Reference Genes

BioGPS Gene:3375 IAPP

COSMIC (genes):IAPP IAPP

CTD Gene:3375 IAPP

dbSNP Gene:3375 IAPP

ENSEMBL:ENSG00000121351 IAPP

HGNC:5329 IAPP

KEGG:hsa:3375 IAPP

Monarch:3375 IAPP

NCBI Gene:3375 IAPP

OMIM:147940 IAPP

UCSC:P10997 IAPP

Reference Transcript

Other Identifiers

11723219_s_at

11723220_at

16749095

207062_PM_at

207062_at

3375

3407771

3407774

3407775

3407776

3407777

3407778

3407779

37871_at

7954377

A_14_P114224

A_14_P200342

A_23_P139648

GE492397

GO:0001540

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0006915

GO:0007165

GO:0007267

GO:0008289

GO:0010739

GO:0012501

GO:0019233

GO:0023052

GO:0030154

GO:0030316

GO:0031333

GO:0042755

GO:0042802

GO:0043065

GO:0043410

GO:0045453

GO:0045671

GO:0045779

GO:0048018

GO:0050850

GO:0050877

GO:0097647

GO:0098772

GO:1905907

HMNXSV003026176

ILMN_1679527

PH_hs_0008384

TC12000230.hg

g4557654_3p_at

Participates

as an output of

PDX1-dependent synthesis of IAPP protein (Homo sapiens)

Other forms of this molecule

IAPP(34-70) [extracellular region]

Cross References

RefSeq

NP_000406.1, NP_001316130.1

OpenTargets

ENSG00000121351

ENSEMBL

ENSP00000240652, ENST00000539393, ENST00000240652, ENSP00000437357

HPA

ENSG00000121351-IAPP

ZINC - Substances

IAPP_HUMAN

ZINC target

P10997

PRO

P10997

Pharos - Targets

P10997

PDB

8AZ3, 8AZ1, 8AZ4, 8F0K, 8AZ2, 7YL0, 7YL7, 7YKW, 5KO0, 7M65, 5KNZ, 7M64, 3DG1, 3FTL, 3G7W, 7BG0, 5MGQ, 6ZRQ, 3FTK, 7YL3, 3G7V, 8F0J, 7M61, 3HGZ, 5K5G, 3FTR, 3FPO, 7M62, 6VW2, 2KB8, 6Y1A, 6ZRF, 3FTH, 3FR1, 6UCK, 6UCJ, 6ZRR, 8AWT, 8R4I, 8AZ7, 8AZ5, 8AZ6, 2L86, 2G48, 8AZ0, 8F2A, 8F2B, 1KUW

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10997 IAPP	2	IAPP(34-70) [extracellular region] (R-HSA-420076) IAPP(1-89) [cytosol] (R-HSA-186631)	0.952	14
UniProt:P14735-1 IDE			0.618	3
UniProt:P56817 BACE1	8	BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.558	2
UniProt:Q9Y5Z0 BACE2			0.558	3

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