PLC-gamma binds to the active receptor

Stable Identifier
R-HSA-186765
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PLC-gamma 1 has been shown to bind to phosphorylated Tyr 1021 of the PDGF beta-receptor with high affinity and to Tyr 1009 with low affinity. In the alpha-receptor, Tyr 988 and Tyr 1018 bind PLC-gamma1. Association of PLC-gamma1 with the activated PDGF receptor has been shown to be necessary for its activation.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
8443409 Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1

Kashishian, A, Cooper, JA

Mol Biol Cell 1993
1396585 Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma

Rönnstrand, L, Mori, S, Arridsson, AK, Eriksson, A, Wernstedt, C, Hellman, U, Claesson-Welsh, L, Heldin, CH

EMBO J 1992
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