GAP binds to PDGF-beta receptors only

Stable Identifier
R-HSA-186798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GTPase-activating protein (GAP) has two SH2 domains which bind only to PDGF beta-receptors on Tyr771. GAP does not bind the alpha-receptor. GAP converts Ras-GTP to Ras-GDP, deactivating Ras.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
1314164 Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo

Kashishian, A, Kazlauskas, A, Cooper, JA

EMBO J 1992
1375321 GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

Kazlauskas, A, Kashishian, A, Cooper, JA, Valius, M

Mol Cell Biol 1992
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