PI3K catalyses the phosphorylation of PIP2 to PIP3

Stable Identifier
R-HSA-186800
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PI3K's preferred substrate is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] which is phosphorylated to the trisphosphate [PI(3,4,5)P3]. PI3-kinase and its products have been found to be of importance in PDGF-stimulated actin reorganization, and directed cell movement, as well as in the stimulation of cell growth and inhibition of apoptosis.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed