Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)

Stable Identifier
R-HSA-186834
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SOS is the guanine nucleotide exchange factor (GEF) for Ras. SOS activates Ras nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).

Literature References
PubMed ID Title Journal Year
8388543 Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types

Satoh, T, Fantl, WJ, Escobedo, JA, Williams, LT, Kaziro, Y

Mol Cell Biol 1993
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed