TRKA activation by NGF

Stable Identifier
R-HSA-187042
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRKA activation by NGF
Click the image above or here to open this pathway in the Pathway Browser
Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible.
Literature References
PubMed ID Title Journal Year
1315923 The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins

Barker, PA, Murphy, RA

Mol Cell Biochem 1992
1844238 The trk family of oncogenes and neurotrophin receptors

Barbacid, M, Lamballe, F, Klein, R

Princess Takamatsu Symp 1991
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
neurotrophin TRK receptor signaling pathway (0048011)
Orthologous Events
TRKA activation by NGF (Bos taurus)
TRKA activation by NGF (Canis familiaris)
TRKA activation by NGF (Gallus gallus)
TRKA activation by NGF (Mus musculus)
TRKA activation by NGF (Rattus norvegicus)
TRKA activation by NGF (Sus scrofa)
TRKA activation by NGF (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-09-07)
Cite Us!