TRKA activation by NGF

Stable Identifier
R-HSA-187042
Type
Pathway
Species
Homo sapiens
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Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible.

Literature References
PubMed ID Title Journal Year
1844238 The trk family of oncogenes and neurotrophin receptors

Lamballe, F, Klein, R, Barbacid, M

Princess Takamatsu Symp 1991
1315923 The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins

Barker, PA, Murphy, RA

Mol Cell Biochem 1992
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Event Information
Orthologous Events
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