Reactome: A Curated Pathway Database

Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

Stable Identifier
R-HSA-187520
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The interaction between the Skp2 subunit of the SCF(Skp2) complex and p27 is dependent upon Cdk2:Cyclin A/E mediated phosphorylation of p27 at Thr 187 (Carrano et al, 1999; Tsvetkov et al, 1999). There is evidence that Cyclin A/B:Cdk1 can also bind and phosphorylate p27 on Thr 187 (Nakayama et al., 2004). This phosphorylation is also essential for the subsequent ubiquitination of p27.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cyclin-dependent protein serine/threonine kinase activity of Cyclin E/A:CDK2:CDKN1A,CDKN1B [nucleoplasm] Cyclin E/A:CDK2:CDKN1A,CDKN1B [nucleoplasm] cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events