Reactome | CUL1 [nucleoplasm]

CUL1 [nucleoplasm]

Stable Identifier

R-HSA-187551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cul-1_1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13616 CUL1

Gene Names

CUL1

Chain

chain:1-776

Reference Genes

BioGPS Gene:8454 CUL1

COSMIC (genes):CUL1 CUL1

CTD Gene:8454 CUL1

dbSNP Gene:8454 CUL1

ENSEMBL:ENSG00000055130 CUL1

HGNC:2551 CUL1

KEGG Gene (Homo sapiens):8454 CUL1

Monarch:8454 CUL1

NCBI Gene:8454 CUL1

OMIM:603134 CUL1

UCSC:Q13616 CUL1

Reference Transcript

Other Identifiers

0000670731

11716819_a_at

11747353_a_at

17053019

1LDJ

1LDK

1U6G

207614_s_at

2676

2874246

3030286

3030287

3030288

3030289

3030290

3030299

3030300

3030301

3030302

3030312

3030313

3030314

3030315

3030316

3030317

3030320

3030321

3030337

3030338

3030339

3030340

3030342

3030343

3030345

3030349

3030354

3030355

3030357

3030359

3030361

3030362

3030363

3030369

39723_at

39724_s_at

3RTR

3TDU

3TDZ

4F52

4P5O

5V89

64584

8137054

8454

A0A090N7U0

A0A0C4DGX4

A_23_P59657

A_24_P303589

AAC36681

AAC50544

AACC02000041

AAI25120

AAI25121

AAM49153

AC005229

AF062536

BC125119

BC125120

BX537409

CAB002676

CAD97651

CCDS34772

CH471146

CUL1

CUL1-201

CUL1-202

CUL1-203

EAL24422

EAW80073

EAW80074

ENSG00000055130

ENSP00000326804

ENSP00000387160

ENSP00000473318

ENST00000325222

ENST00000325222.8

ENST00000409469

ENST00000409469.5

ENST00000602748

ENST00000602748.5

EntrezGene:8454

EntrezGene:CUL1

g4503160_3p_a_at

GE54578

GO:0000082

GO:0000086

GO:0000209

GO:0000278

GO:0002223

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006511

GO:0006513

GO:0006879

GO:0006915

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009887

GO:0010265

GO:0010972

GO:0016032

GO:0016055

GO:0016567

GO:0019005

GO:0019899

GO:0022607

GO:0031146

GO:0031461

GO:0031625

GO:0032991

GO:0038061

GO:0038095

GO:0042592

GO:0043161

GO:0043226

GO:0043687

GO:0044403

GO:0048856

GO:0050852

GO:0051403

GO:0065003

GO:0070498

GO:0097193

GO:1901990

GO:1990452

HGNC:2551

HPA064584

ILMN_1749629

IPR001373

IPR016157

IPR016158

IPR016159

IPR019559

IPR036317

IPR036388

IPR036390

MIM:603134

NM_003592

NP_003583

PF00888

PF10557

PH_hs_0023905

SM00182

SM00884

TC07000969.hg

U58087

U58087_at

UPI00001286E6

XM_011516629

XP_011514931

Participant Of

hasComponent

Other forms of this molecule

G76-NEDD8-K720-CUL1 [cytosol]

CUL1 [cytosol]

Inferred To

Cul1 [nucleoplasm] (Mus musculus)

CUL1 [nucleoplasm] (Bos taurus)

CUL1 [nucleoplasm] (Caenorhabditis elegans)

CUL1 [nucleoplasm] (Canis familiaris)

CUL1 [nucleoplasm] (Danio rerio)

CUL1 [nucleoplasm] (Dictyostelium discoideum)

CUL1 [nucleoplasm] (Drosophila melanogaster)

CUL1 [nucleoplasm] (Gallus gallus)

CUL1 [nucleoplasm] (Rattus norvegicus)

CUL1 [nucleoplasm] (Saccharomyces cerevisiae)

CUL1 [nucleoplasm] (Schizosaccharomyces pombe)

CUL1 [nucleoplasm] (Sus scrofa)

CUL1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011514931.1, XP_011514932.1, NP_003583.2, XP_005250117.1, XP_011514933.1, XP_011514934.1

OpenTargets

ENSG00000055130

GeneCards

Q13616

PRO

Q13616

PDB

3TDZ, 4P5O, 1LDK, 1LDJ, 3RTR, 3TDU, 5V89, 4F52, 1U6G

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.973	24
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.95	12
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.942	10
UniProt:Q86VP6 CAND1	5	CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [cytosol] (R-HSA-5691146)	0.917	21
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.908	8
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.87	6
UniProt:P61081 UBE2M	5	AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.786	5
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.758	4
UniProt:Q13309 SKP2	2	SKP2 [nucleoplasm] (R-HSA-975554) SKP2 [cytosol] (R-HSA-975495)	0.744	9
UniProt:Q9NRD1 FBXO6	1	FBXO6 [cytosol] (R-HSA-391296)	0.669	3
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.669	4
UniProt:P41002 CCNF	1	CCNF [cytosol] (R-HSA-8862602)	0.662	5
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.643	4
IntAct:EBI-4399559 UBIQ			0.623	3
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.623	7
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.609	2
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.597	5
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.597	4
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.589	2
UniProt:Q8TCJ0 FBX25			0.577	3
UniProt:O60826 CCDC22	2	CCDC22 [cytosol] (R-HSA-8955640) CCDC22 [nucleoplasm] (R-HSA-8955644)	0.576	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.564	2
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [cytosol] (R-HSA-8951781) DCUN1D1 [nucleoplasm] (R-HSA-8952487)	0.564	3
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.564	8
UniProt:Q13309-1 SKP2			0.564	3
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628)	0.558	2
UniProt:Q83730 MT5			0.556	5
UniProt:Q8BFZ4	1	FBXL21 [cytosol] (R-MMU-8862606)	0.547	3
UniProt:Q8C4V4 Fbxl3	2	FBXL3 [cytosol] (R-MMU-391289) Fbxl3 [nucleoplasm] (R-MMU-508623)	0.547	3
UniProt:P49427 CDC34	4	Ub-C93-CDC34 [nucleoplasm] (R-HSA-8864204) Ub-C93-CDC34 [cytosol] (R-HSA-8864170) CDC34 [nucleoplasm] (R-HSA-8852125) CDC34 [cytosol] (R-HSA-947621)	0.544	3
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.527	2
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.527	2
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.527	2
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:Q6TVW2 Q6TVW2			0.499	5