Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Stable Identifier
R-HSA-187552
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The association of Cks1 with both Skp2 and phosphorylated p27 promotes a tight interaction between p27 and the SCF complex (Hao et al., 2005).

Literature References
PubMed ID Title Journal Year
16209941 Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

Hao, B, Zheng, N, Schulman, BA, Wu, G, Miller, JJ, Pagano, M, Pavletich, NP

Mol Cell 2005
15199159 Noncatalytic requirement for cyclin A-cdk2 in p27 turnover

Zhu, XH, Nguyen, H, Halicka, HD, Traganos, F, Koff, A

Mol Cell Biol 2004
11231585 The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

Ganoth, D, Bornstein, G, Ko, TK, Larsen, B, Tyers, M, Pagano, M, Hershko, A

Nat Cell Biol 2001
10375532 p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

Tsvetkov, LM, Yeh, KH, Lee, SJ, Sun, H, Zhang, H

Curr Biol 1999
Participants
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