Degradation of ubiquitinated p27/p21 by the 26S proteasome

Stable Identifier
R-HSA-187574
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Degradation of ubiquitinated p27/p21 by the 26S proteasome
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Following ubiquitination by the SCF(Skp2):Cks1 complex, phospho-p27/p21 is degraded by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
10559916 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Carrano, AC, Eytan, E, Hershko, A, Pagano, M

Nat Cell Biol 1999
10375532 p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

Tsvetkov, LM, Yeh, KH, Lee, SJ, Sun, H, Zhang, H

Curr Biol 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Gallus gallus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)
Authored
Pagano, M  (2006-09-19)
Reviewed
Coqueret, O  (2006-10-06)
Created
Matthews, L  (2006-09-20)
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