Degradation of ubiquitinated p27/p21 by the 26S proteasome

Stable Identifier
R-HSA-187574
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Following ubiquitination by the SCF(Skp2):Cks1 complex, phospho-p27/p21 is degraded by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
10375532 p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

Tsvetkov, LM, Yeh, KH, Lee, SJ, Sun, H, Zhang, H

Curr Biol 1999
10559916 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Carrano, AC, Eytan, E, Hershko, A, Pagano, M

Nat Cell Biol 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed