Degradation of ubiquitinated p27/p21 by the 26S proteasome

Stable Identifier
R-HSA-187574
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Following ubiquitination by the SCF(Skp2):Cks1 complex, phospho-p27/p21 is degraded by the 26S proteasome.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [nucleoplasm]
Physical Entity
Activity
Orthologous Events