Reactome: A Curated Pathway Database

Degradation of ubiquitinated p27/p21 by the 26S proteasome

Stable Identifier
R-HSA-187574
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Following ubiquitination by the SCF(Skp2):Cks1 complex, phospho-p27/p21 is degraded by the 26S proteasome.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endopeptidase activity of 26S proteasome [nucleoplasm] 26S proteasome [nucleoplasm] endopeptidase activity (0004175)
Orthologous Events