Ubiquitination of phospho-p27/p21

Stable Identifier
R-HSA-187575
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Once in tight contact with the SCF (Skp2):Cks1 complex, phosphorylated p27/p21 is ubiquitinated.

Literature References
PubMed ID Title Journal Year
11231585 The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

Ganoth, D, Bornstein, G, Ko, TK, Larsen, B, Tyers, M, Pagano, M, Hershko, A

Nat Cell Biol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created