Reactome: A Curated Pathway Database

Ubiquitination of phospho-p27/p21

Stable Identifier
R-HSA-187575
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once in tight contact with the SCF (Skp2):Cks1 complex, phosphorylated p27/p21 is ubiquitinated.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] ubiquitin-protein transferase activity (0004842)
Orthologous Events