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MAPKAPK2 [cytosol]
Stable Identifier
R-HSA-187743
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MAP kinase-activated protein kinase 2, MKK2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
MAPKAPK2 phosphorylates HSF1 (Homo sapiens)
MAPKAPK2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)
MAPKAP kinase [cytosol] (Homo sapiens)
MAPKAPK2 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)
MAPKAP kinase [cytosol] (Homo sapiens)
MAPKAPK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49137 MAPKAPK2
Gene Names
MAPKAPK2
Chain
chain:1-400
Reference Genes
BioGPS Gene:9261 MAPKAPK2
COSMIC (genes):MAPKAPK2 MAPKAPK2
CTD Gene:9261 MAPKAPK2
dbSNP Gene:9261 MAPKAPK2
ENSEMBL:ENSG00000162889 MAPKAPK2
HGNC:6887 MAPKAPK2
KEGG Gene (Homo sapiens):9261 MAPKAPK2
Monarch:9261 MAPKAPK2
NCBI Gene:9261 MAPKAPK2
OMIM:602006 MAPKAPK2
UCSC:P49137 MAPKAPK2
Reference Transcript
RefSeq:NM_032960.3 MAPKAPK2
RefSeq:NM_004759.4 MAPKAPK2
Other Identifiers
0000070164
0006290551
11719368_s_at
11730896_a_at
1439_s_at
1469_at
16676643
201460_at
201461_s_at
215050_x_at
2376923
2376924
2376925
2376926
2376949
2376950
2376951
2376953
2376954
2376956
2376957
2376959
2376962
2376964
2376965
2376966
2376967
2376968
36179_at
36180_s_at
7909236
9261
A_14_P129763
A_23_P201483
A_23_P350467
GO:0000165
GO:0000166
GO:0000187
GO:0002224
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0006691
GO:0006810
GO:0006950
GO:0006954
GO:0006974
GO:0007165
GO:0008150
GO:0009056
GO:0009058
GO:0009931
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0032496
GO:0032675
GO:0032680
GO:0034097
GO:0034641
GO:0034655
GO:0035556
GO:0035924
GO:0038066
GO:0042535
GO:0043167
GO:0043226
GO:0043488
GO:0044281
GO:0044351
GO:0046777
GO:0048010
GO:0048255
GO:0048839
GO:0048856
GO:0051019
GO:0070062
GO:0070935
GO:1900034
Hs.75074.0.A2_3p_at
ILMN_1656144
ILMN_1774844
PH_hs_0004270
TC01001727.hg
U12779_at
X75346_s_at
g10863900_3p_a_at
Participant Of
hasMember
MAPKAP kinase [cytosol]
Other forms of this molecule
p-T222,S272-MAPKAPK2 [nucleoplasm]
p-S272,T222,T334-MAPKAPK2 [cytosol]
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
MAPKAPK2 [nucleoplasm]
Inferred To
mapkapk2a [cytosol] (Danio rerio)
MAPk-Ak2 [cytosol] (Drosophila melanogaster)
Mapkapk2 [cytosol] (Mus musculus)
Mapkapk2 [cytosol] (Rattus norvegicus)
fhkA [cytosol] (Dictyostelium discoideum)
MAPKAPK2 [cytosol] (Bos taurus)
MAPKAPK2 [cytosol] (Gallus gallus)
MAPKAPK2 [cytosol] (Sus scrofa)
mapkapk2 [cytosol] (Xenopus tropicalis)
DYRK3 [cytosol] (Canis familiaris)
CPK2 [cytosol] (Plasmodium falciparum)
mak-2 [cytosol] (Caenorhabditis elegans)
Cross References
RefSeq
NP_004750.1
,
NP_116584.2
ZINC - World Drugs
MAPK2_HUMAN
OpenTargets
ENSG00000162889
ZINC - Substances
MAPK2_HUMAN
ZINC - Biogenic
MAPK2_HUMAN
ZINC target
P49137
PRO
P49137
PDB
1NXK
,
3KGA
,
3FYK
,
3M42
,
4TYH
,
3R2Y
,
2ONL
,
3FYJ
,
3R30
,
2OZA
,
3WI6
,
6TCA
,
3M2W
,
3KA0
,
2JBP
,
2PZY
,
3GOK
,
3R2B
,
3KC3
,
1KWP
,
1NY3
,
2JBO
,
3A2C
,
2OKR
,
3FPM
,
2P3G
ZINC - Investigational
MAPK2_HUMAN
ZINC - Metabolites
MAPK2_HUMAN
HPA
ENSG00000162889-MAPKAPK2
GeneCards
P49137
Ensembl
ENSP00000356070
,
ENST00000294981
,
ENST00000367103
,
ENSP00000294981
,
ENSG00000162889
ZINC - Predictions - Purchasable
MAPK2_HUMAN
HMDB Protein
HMDBP02904
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16539 MAPK14
7
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.912
9
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.609
3
UniProt:Q00613 HSF1
11
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
HSF1 [cytosol]
(R-HSA-3371452)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
0.602
5
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.488
2
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