Engulfed CpG DNA binds to endosomal C-ter TLR9

Stable Identifier
R-HSA-187895
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
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Engulfed CpG DNA binds to endosomal C-ter TLR9
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Synthetic oligodeoxynucleotides (ODN) expressing non-methylated CpG motifs patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern by TLR9, and triggers a rapid innate immune response.

Literature References
PubMed ID Title Journal Year
15207506 The immunobiology of the TLR9 subfamily

Wagner, H

Trends Immunol 2004
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Cameron, JL, Brooks, JC, Chockalingam, A, Leifer, CA

Eur J Immunol 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
C-ter TLR9 dimer:HCQ [endosome membrane] (Homo sapiens)
Positively by
Regulator
EEA1:EEA1 [endosome membrane] (Homo sapiens)
Orthologous Events
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)
Created
de Bono, B  (2006-09-28)
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