Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
Stable Identifier
R-HSA-187926
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
Participants
components
CCNA:CDK2 [nucleoplasm]
(Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm]
(Homo sapiens)
Participates
as an input of
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)
as an output of
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
This entity regulates
Negatively
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2
(Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1
(Homo sapiens)
Inferred To
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Caenorhabditis elegans)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Canis familiaris)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Danio rerio)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Gallus gallus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Rattus norvegicus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Sus scrofa)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
