CAK-mediated phosphorylation of Cyclin A:Cdk2

Stable Identifier
R-HSA-187949
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK kinase activity. The association of p21/p27 with the Cyclin A/E:Cdk2 complex prevents CAK mediated phosphorylation of Cdk2 (Aprelikova et al., 1995).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of CAK [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed