Reactome | p-T160-CDK2 [nucleoplasm]

p-T160-CDK2 [nucleoplasm]

Stable Identifier

R-HSA-187967

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Cdk2(Thr160)

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        p-T160-CDK2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CDK2 phosphorylates TP53 (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)
        
        CCNA:p-CDK1/2 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        p-T160-CDK2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24941 CDK2

Gene Names

CDK2, CDKN2

Chain

chain:1-298

Reference Genes

BioGPS Gene:1017 CDK2

COSMIC (genes):CDK2 CDK2

CTD Gene:1017 CDK2

dbSNP Gene:1017 CDK2

ENSEMBL:ENSG00000123374 CDK2

ENSEMBL_homo_sapiens_GENE:ENSG00000123374.11 CDK2

HGNC:1771 CDK2

KEGG Gene (Homo sapiens):1017 CDK2

Monarch:1017 CDK2

NCBI Gene:1017 CDK2

OMIM:116953 CDK2

UCSC:P24941 CDK2

Reference Transcript

Other Identifiers

1017

11720781_a_at

11720782_a_at

11741208_a_at

16752305

1792_g_at

1833_at

204252_PM_at

204252_at

211804_PM_s_at

211804_s_at

3417147

3417148

3417149

3417152

3417153

3417154

3417155

3417157

3417158

3417159

3417160

74635_at

7956076

A_14_P122617

A_14_P129989

A_23_P98898

GE724134

GE81070

GO:0000082

GO:0000086

GO:0000122

GO:0000166

GO:0000278

GO:0000287

GO:0000307

GO:0000781

GO:0000793

GO:0000805

GO:0000806

GO:0001673

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005768

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006260

GO:0006281

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006468

GO:0006813

GO:0006974

GO:0007010

GO:0007049

GO:0007099

GO:0007165

GO:0007265

GO:0007346

GO:0008284

GO:0010033

GO:0010389

GO:0010468

GO:0015030

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019904

GO:0022414

GO:0023052

GO:0030163

GO:0030332

GO:0031410

GO:0031453

GO:0031571

GO:0032298

GO:0035173

GO:0036211

GO:0043226

GO:0043687

GO:0045740

GO:0045893

GO:0046872

GO:0051298

GO:0051301

GO:0051321

GO:0071732

GO:0090398

GO:0097123

GO:0097124

GO:0097134

GO:0097135

GO:0097472

GO:0106310

GO:0140096

GO:1905784

HMNXSV003002576

ILMN_1653443

ILMN_1665559

M68520_at

PH_hs_0001687

TC12000496.hg

g180177_3p_at

g3551190_3p_a_at

Participates

as a component of

Other forms of this molecule

p-Y15-CDK2 [nucleoplasm]

p-CDK2 [nucleoplasm]

CDK2 [cytosol]

CDK2 [nucleoplasm]

Inferred To

phospho-p-T160-CDK2 [nucleoplasm] (Bos taurus)

phospho-p-T160-CDK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T160-CDK2 [nucleoplasm] (Danio rerio)

phospho-p-T160-CDK2 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T160-CDK2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T160-CDK2 [nucleoplasm] (Gallus gallus)

phospho-p-T160-CDK2 [nucleoplasm] (Mus musculus)

phospho-p-T160-CDK2 [nucleoplasm] (Rattus norvegicus)

phospho-p-T160-CDK2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-T160-CDK2 [nucleoplasm] (Sus scrofa)

phospho-p-T160-CDK2 [nucleoplasm] (Xenopus tropicalis)

phospho-CDK2 [nucleoplasm] (Canis familiaris)

Modified Residues

Name

O-phospho-L-threonine at 160

Coordinate

160

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001277159.1, NP_439892.2, NP_001789.2

ZINC - World Drugs

CDK2_HUMAN

Guide to Pharmacology - Targets

1973

OpenTargets

ENSG00000123374

ZINC - FDA approved

CDK2_HUMAN

ZINC - Substances

CDK2_HUMAN

ZINC - Biogenic

CDK2_HUMAN

ZINC target

P24941

PRO

P24941

PDB

4I3Z, 3R1Y, 1OIR, 3SQQ, 1DM2, 8FP5, 8BYA, 3S00, 1OKV, 3R9D, 1CKP, 2WMA, 2R3Q, 8ERD, 2UZL, 4EOL, 2X1N, 6GUC, 7B5R, 2W17, 2VTL, 6YL6, 3RMF, 3LE6, 8UV0, 4EK6, 2BHH, 3R7E, 1KE6, 2VTQ, 7NVQ, 4ACM, 3RK9, 1PXO, 6Q49, 3QQK, 1Y8Y, 3F5X, 6RIJ, 2CJM, 4GCJ, 4BCO, 4CFV, 1PYE, 1URC, 7S85, 5UQ1, 3LFN, 6Q4E, 4EOP, 6GUK, 5OSJ, 4FKS, 1B39, 4RJ3, 8BZO, 3ULI, 3FZ1, 7ACK, 1E9H, 1PXK, 3EID, 1OKW, 3R9H, 4FKV, 5MHQ, 3QL8, 2VTO, 8H6P, 1WCC, 7UXI, 5L2W, 5AND, 1PXM, 7MKX, 3QQF, 3QZI, 8OR0, 4FKO, 7RWF, 2VTI, 4KD1, 1URW, 3R8P, 5ANJ, 2C6I, 1OIT, 1R78, 3R7I, 2J9M, 6Q4J, 2IW6, 4EK8, 3UNJ, 2B52, 1PXI, 4EZ3, 2B54, 1H1P, 1W0X, 3PXY, 4FKG, 1AQ1, 5IEY, 1H24, 3WBL, 2WMB, 3R7Y, 4BCP, 3QWK, 4CFW, 3SW4, 6Q4A, 7B7S, 3QXP, 8ERN, 4EK3, 2VV9, 6Q3B, 1BUH, 3TI1, 3RAK, 4FKT, 2VTA, 4FX3, 2JGZ, 4CFM, 5D1J, 4BCK, 2C5O, 7VDU, 3QX2, 6YLK, 4FKW, 2C68, 6GUE, 3TIY, 2WFY, 3RPV, 4FKP, 2C5X, 2C6L, 3QZF, 1OGU, 3R8U, 2XMY, 2UZD, 3IG7, 2WHB, 2C4G, 3QTX, 3RNI, 1H1Q, 2DUV, 1JSV, 1H25, 8H6T, 4EZ7, 3QTR, 3PXZ, 2R3O, 6GVA, 4FKI, 3R6X, 8OR4, 2A0C, 7S9X, 3R83, 2C6O, 3SW7, 6Q4F, 3PXF, 5UQ2, 7SA0, 1H07, 1JVP, 5OSM, 2BTR, 1FVT, 2R3R, 1E1V, 6SG4, 2R3K, 8OY2, 2CCH, 3EOC, 2W1H, 3ROY, 6Q4K, 7RXO, 2R3I, 2WXV, 2R3G, 2VTM, 3RPY, 3IGG, 4D1X, 4EOM, 5ANE, 3EZR, 7RA5, 6Q3C, 1FVV, 7ZPC, 7UXK, 5ANK, 2R3M, 6ATH, 3S0O, 5JQ5, 3R28, 3RAL, 4EOQ, 3EJ1, 3QQL, 3QTS, 4EOI, 5IF1, 3QQG, 1KE7, 6JGM, 6Q4B, 2UUE, 2UZN, 4BZD, 2FVD, 1H08, 3BHT, 3RKB, 3QTZ, 1VYZ, 5NEV, 3R9N, 4II5, 3RM6, 7UG1, 2VTP, 1OL1, 8VQ3, 3R1Q, 2W05, 3S1H, 2BKZ, 2VTS, 1W8C, 3RJC, 3LFQ, 6GUF, 2WPA, 3MY5, 4EON, 6Q4G, 3RZB, 1YKR, 1PXP, 4EOR, 3UNK, 2CLX, 5OO0, 1KE8, 1Y91, 3QQH, 3RK5, 1OIU, 2BHE, 4EOJ, 8FOW, 3EZV, 5LMK, 3QRT, 3DDP, 4BCQ, 1OI9, 3R7U, 3R8V, 2VTR, 4CFX, 8CUR, 2VTJ, 4EK4, 1GII, 5UQ3, 5ANO, 3R9O, 3R8L, 3TNW, 1OIQ, 7KJS, 1DI8, 4FKU, 4BCM, 4CFN, 2I40, 4BGH, 1PXJ, 2WIH, 1H00, 4FKJ, 2XNB, 4LYN, 6Q4C, 1PXL, 5ANG, 1OL2, 3QZG, 8VQ4, 3LFS, 3TIZ, 2UZE, 6Q3F, 5JQ8, 4FKQ, 1PXN, 3PJ8, 2B53, 1H1R, 1FIN, 1HCK, 7S4T, 2IW8, 5IEV, 2VTN, 3QX4, 3PY0, 1OIY, 5CYI, 7M2F, 6OQI, 3DOG, 3R71, 3PXQ, 3R8Z, 3DDQ, 1H26, 3R7V, 2B55, 2A4L, 1V1K, 1B38, 5FP5, 4NJ3, 2V0D, 4EK5, 2UZB, 3QU0, 3R8M, 2IW9, 2C5V, 2WIP, 6Q4H, 3RAH, 2R64, 2C6K, 2C5N, 2C6T, 4BCN, 7E34, 3R73, 4CFU, 4FKL, 1PKD, 1H0V, 2C69, 3QZH, 1GIH, 4D1Z, 6GUH, 2VTH, 2C5Y, 2C6M, 3RPO, 3QHR, 4FKR, 1PW2, 3S2P, 3QTU, 5A14, 1GY3, 1F5Q, 2UZO, 5K4J, 2R3H, 3PY1, 1JST, 1HCL, 5OO1, 8FP0, 1H1S, 6Q48, 1P2A, 6GUB, 2BTS, 2VTT, 3PXR, 3QWJ, 1H27, 1PF8, 3QXO, 2CCI, 6YL1, 8B54, 3BHU, 3RM7, 7S7A, 2R3J, 3R1S, 3RAI, 2W06, 6P3W, 7B5L, 2WEV, 3QRU, 1E1X, 2R3N, 4EOK, 7S84, 3NS9, 1H0W, 6INL, 1H28, 2G9X, 5ANI, 2R3L, 2BPM, 2EXM, 3QHW, 3RPR, 6Q4D, 2R3F, 1P5E, 1KE5, 1QMZ, 3QTW, 1W98, 5FP6, 1GZ8, 2V22, 2DS1, 4EOS, 6Q4I, 3QQJ, 3RK7, 1KE9, 7QHL, 2R3P, 3QTQ, 1JSU, 5IEX, 2VU3, 1FQ1, 5OO3, 1VYW, 7RWE, 3BHV, 4ERW, 1G5S, 1GIJ, 1H01, 4EOO

ZINC - Investigational

CDK2_HUMAN

ZINC - Metabolites

CDK2_HUMAN

GeneCards

P24941

HPA

ENSG00000123374-CDK2

Ensembl

ENST00000266970, ENSG00000123374, ENST00000354056, ENSP00000243067, ENSP00000266970

Pharos - Targets

P24941

ZINC - Predictions - Purchasable

CDK2_HUMAN

HMDB Protein

HMDBP01383

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.977	33
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.976	32
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.974	31
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.966	26
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.949	28
UniProt:O96020 CCNE2	3	Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [cytosol] (R-HSA-157452) CCNE2 [nucleoplasm] (R-HSA-68367)	0.937	15
UniProt:Q16667 CDKN3			0.92	10
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.892	10
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.892	12
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.877	11
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.845	8
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.837	9
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.822	6
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.818	6
UniProt:P33552 CKS2			0.788	7
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.784	7
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.729	5
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.725	6
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.725	7
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.725	5
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.713	3
UniProt:Q8TD08 MK15			0.708	6
UniProt:P30279 CCND2	2	CCND2 [cytosol] (R-HSA-68340) CCND2 [nucleoplasm] (R-HSA-113827)	0.659	4
UniProt:Q00526 CDK3			0.643	6
UniProt:P49918 CDKN1C	3	p-Y91-CDKN1C [cytosol] (R-HSA-8942606) CDKN1C [cytosol] (R-HSA-8941913) CDKN1C [nucleoplasm] (R-HSA-8948130)	0.643	5
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.643	4
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.643	4
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.643	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.643	4
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.643	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.633	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.623	3
UniProt:Q9UQR0-1 SCML2			0.612	7
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.576	4
UniProt:P03129 VE7			0.564	2
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.564	2
UniProt:P51943 Ccna2	4	Ccna2 [nucleoplasm] (R-MMU-6783099) Ccna2 [nucleoplasm] (R-MMU-1362307) Ccna2 [cytosol] (R-MMU-157444) Ccna2 [nucleoplasm] (R-MMU-68905)	0.558	2
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P30274 CCNA2			0.544	2
UniProt:Q08619 IFI5B			0.544	2
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.527	2
UniProt:Q5T5M9 CCNJ			0.527	2
UniProt:P49918-2 CDKN1C			0.527	2
UniProt:Q86YS7 C2CD5	2	p-S197-C2CD5 [plasma membrane] (R-HSA-5260194) C2CD5 [plasma membrane] (R-HSA-5216175)	0.527	2
UniProt:Q00536 CDK16			0.527	2
UniProt:Q9Y3Z3 SAMHD1	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.527	3
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.527	3
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:Q14004 CDK13	3	CDK13 [nucleoplasm] (R-HSA-6797014) CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374) CDK13 [extracellular region] (R-HSA-6806442)	0.527	2
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.527	2
UniProt:Q9BY12 SCAPE			0.524	3
UniProt:Q9UQR0 SCML2			0.499	3
UniProt:Q8NA61-2 CBY2			0.488	2
UniProt:Q8N448 LNX2			0.488	2

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