The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex

Stable Identifier
R-HSA-188345
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
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Binding of the MYC:MAX heterodimer to MYC response elements in the first and second intron of the CDC25A gene activates CDC25A transcription in mid to late G1 (Galaktionov et al. 1996).
Transcription of the CDC25A gene can be directly activated by E2F1 (DeGregori et al. 1995, Vigo et al. 1999).
Transcription of the CDC25A gene is directly inhibited by the DREAM complex (Litovchick et al. 2007).
Literature References
PubMed ID Title Journal Year
8700224 Cdc25 cell-cycle phosphatase as a target of c-myc

Galaktionov, K, Chen, X, Beach, D

Nature 1996
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

Litovchick, L, Sadasivam, S, Florens, LA, Zhu, X, Swanson, SK, Velmurugan, S, Chen, R, Washburn, MP, Liu, XS, DeCaprio, JA

Mol Cell 2007
10454584 CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

Vigo, E, Muller, H, Prosperini, E, Hateboer, G, Cartwright, P, Moroni, MC, Helin, K

Mol Cell Biol 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
Active Unit
DREAM complex [nucleoplasm]
Positively by
Regulator
MYC:MAX:CDC25A gene [nucleoplasm] (Homo sapiens)
Active Unit
MYC:MAX [nucleoplasm]
Regulator
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Matthews, L  (2006-09-29)
Reviewed
Coqueret, O  (2006-10-06)
MacPherson, D  (2011-08-25)
Created
Matthews, L  (2006-10-10)
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