Association of Cyclin A:Cdk2 with Cdh1

Stable Identifier
R-HSA-188371
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cyclin A-Cdk2 prevents unscheduled APC reactivation during S phase by binding and subsequently phosphorylating Cdh1. Phosphorylation-dependent dissociation of the Cdh1-activating subunit inhibits the APC/C.

Literature References
PubMed ID Title Journal Year
11340163 A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

Sorensen, CS, Lukas, C, Kramer, ER, Peters, JM, Lukas, J

Mol Cell Biol 2001
Participants
Participant Of
Orthologous Events
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Created