Association of Rb with Cyclin E:Cdk2 complexes

Stable Identifier
R-HSA-188386
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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pRB contains, in its C terminus, a cyclin-cdk interaction motif like that found in E2F1 and p21 that enables it to be recognized and phosphorylated by cyclin-cdk complexes.

Literature References
PubMed ID Title Journal Year
9482921 Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein

Kelly, BL, Wolfe, KG, Roberts, JM

Proc Natl Acad Sci U S A 1998
9891042 Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

Adams, PD, Li, X, Sellers, WR, Baker, KB, Leng, X, Harper, JW, Taya, Y, Kaelin WG, Jr

Mol Cell Biol 1999
Participants
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