Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)

Stable Identifier
R-HSA-188467
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FAD-linked mitochondrial glycerol 3-phosphate dehydrogenase (GPD2, alias: mGPDH) and its NAD-linked cytosolic isoform (GPD1, alias:cGPDH) constitute glycerol phosphate shuttle. GPD2 catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Impaired activity of GPD2 has been suggested to be one of the primary causes of insulin secretory defects in beta-cells and thus it is a candidate gene for type 2 diabetes.

Literature References
PubMed ID Title Journal Year
8163052 Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients

Fernandez-Alvarez, J, Conget, I, Rasschaert, J, Sener, A, Gomis, R, Malaisse, WJ

Diabetologia 1994
7821823 The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA

Lehn, DA, Brown, LJ, Simonson, GD, Moran, SM, MacDonald, MJ

Gene 1994
8687421 Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene

Matsutani, A, Takeuchi, Y, Ishihara, H, Kuwano, S, Oka, Y

Biochem Biophys Res Commun 1996
  Biochemistry, 4th ed

Stryer, L

  1995
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Catalyst Activity
Title
glycerol-3-phosphate dehydrogenase (quinone) activity of GPD2 [mitochondrial inner membrane]
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Activity
Orthologous Events
Cross References
Rhea
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Created