Assembly of M2 tetramers

Stable Identifier
R-HSA-188544
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Assembly of M2 tetramers
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The M2 from influenza A virus is a 97-residue protein with a single transmembrane helix that associates to form a tetramer in the endoplasmic reticulum (Salom et al, 2000). A 15-20-residue segment C-terminal to the membrane-spanning region has been postulated to aid in the stabilization of the tetrameric assembly (Kochendoerfer et al 1999).
Literature References
PubMed ID Title Journal Year
11087364 pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus

DeGrado, WF, Salom, D, Hill, BR, Lear, JD

Biochemistry 2000
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Steel, J  (2007-05-01)
Reviewed
Squires, B  (2007-05-01)
Rush, MG  (2007-05-01)
Created
Gillespie, ME  (2006-10-17)
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