FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3

Stable Identifier
R-HSA-1888198
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Expression of FGFR1OP-FGFR1 in both Ba/F3 and Cos-1 cells leads to phosphorylation of STAT1 and STAT3 but not STAT5, and to activation of a STAT1/3-responsive reporter when expressed in NIH3T3 cells (Guasch, 2001). Activation of STAT proteins has also been shown to be oncogenic in the context of derivatives of FGFR1, 3 and 4 that lack the extracellular domain and are are targetted to the plasma membrane by a myristylation signal (Hart et al, 2000).

Literature References
PubMed ID Title Journal Year
10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Hart, KC, Robertson, SC, Kanemitsu, MY, Meyer, AN, Tynan, JA, Donoghue, DJ

Oncogene 2000
11689702 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways

Guasch, G, Ollendorff, V, Borg, JP, Birnbaum, D, P├ębusque, MJ

Mol Cell Biol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
precursor lymphoblastic lymphoma/leukemia 5600
subacute leukemia 3264
myelodysplastic myeloproliferative cancer 4972 Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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Created