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KPNA1 [nucleoplasm]
Stable Identifier
R-HSA-188865
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Karyopherin alpha
Locations in the PathwayBrowser for interactor UniProt:Q8IY92 SLX4
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Transport of Ribonucleoproteins into the Host Nucleus (Homo sapiens)
Release of the RNP into the host cell nucleus (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Translocation of ISGF3 complex to nucleus (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)
KPNA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52294 KPNA1
Gene Names
KPNA1, RCH2
Chain
chain:1-538, initiator methionine:, chain:2-538
Reference Genes
BioGPS Gene:3836 KPNA1
COSMIC (genes):KPNA1 KPNA1
CTD Gene:3836 KPNA1
dbSNP Gene:3836 KPNA1
ENSEMBL:ENSG00000114030 KPNA1
ENSEMBL_homo_sapiens_GENE:ENSG00000114030.13 KPNA1
HGNC:6394 KPNA1
KEGG Gene (Homo sapiens):3836 KPNA1
Monarch:3836 KPNA1
NCBI Gene:3836 KPNA1
OMIM:600686 KPNA1
UCSC:P52294 KPNA1
Reference Transcript
RefSeq:NM_002264.3 KPNA1
RefSeq:XM_005247437.3 KPNA1
Other Identifiers
11734667_a_at
11734668_at
11734669_at
11734670_at
11734671_a_at
16958100
202055_PM_at
202055_at
202056_PM_at
202056_at
202057_PM_at
202057_at
202058_PM_s_at
202058_s_at
202059_PM_s_at
202059_s_at
213741_PM_s_at
213741_s_at
2691984
2691985
2691986
2691987
2691988
2691989
2691990
2691991
2691992
2691993
2691994
2691995
2691996
2691997
2691998
2691999
2692000
2692001
2692002
2692003
2692006
2692007
2692010
2692013
2692020
2692021
2692022
2692023
2692024
2692026
2692027
2692038
2692039
2692040
2692045
2692056
2692057
2692058
2692059
3836
40474_r_at
78107_at
8089999
A_33_P3214879
GE58808
GO:0000018
GO:0005515
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005737
GO:0005829
GO:0006310
GO:0006606
GO:0006607
GO:0006886
GO:0006913
GO:0008139
GO:0012501
GO:0014069
GO:0014841
GO:0014901
GO:0015031
GO:0023052
GO:0030425
GO:0042564
GO:0042981
GO:0043226
GO:0043403
GO:0048856
GO:0060828
GO:0061608
GO:0098978
GO:0099527
GO:0140104
HMNXSV003023032
Hs.169149.0.S3_3p_at
Hs.169149.0.S4_3p_at
Hs.169149.0.S5_3p_at
Hs.169149.1.S1_3p_x_at
ILMN_1676005
PH_hs_0031932
S75295_at
TC03001704.hg
TC03003052.hg
g12803140_3p_a_at
g4504894_3p_a_at
Participates
as an output of
Release of the RNP into the host cell nucleus (Homo sapiens)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)
Translocation of ISGF3 complex to nucleus (Homo sapiens)
as a component of
RNP Complex:Karyopherin alpha [nucleoplasm] (Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
as a member of
Importin alpha [nucleoplasm] (Homo sapiens)
KPNA1,KPNA6 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
KPNA1 [cytosol]
Inferred To
Homologues of KPNA1 [nucleoplasm]
(Schizosaccharomyces pombe)
imp1 [nucleoplasm]
(Schizosaccharomyces pombe)
Kpna1 [nucleoplasm]
(Mus musculus)
Kpna1 [nucleoplasm]
(Rattus norvegicus)
KPNA1 [nucleoplasm]
(Bos taurus)
KPNA1 [nucleoplasm]
(Caenorhabditis elegans)
KPNA1 [nucleoplasm]
(Canis familiaris)
KPNA1 [nucleoplasm]
(Gallus gallus)
KPNA1 [nucleoplasm]
(Sus scrofa)
kpna1 [nucleoplasm]
(Xenopus tropicalis)
Kap-alpha1 [nucleoplasm]
(Drosophila melanogaster)
cut15 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_002255.3
,
XP_005247494.1
OpenTargets
ENSG00000114030
GeneCards
P52294
HPA
ENSG00000114030-KPNA1
Ensembl
ENST00000344337
,
ENSP00000343701
,
ENSG00000114030
PRO
P52294
Pharos - Targets
P52294
PDB
2JDQ
,
4B18
,
6WX9
,
3TJ3
HMDB Protein
HMDBP08456
Interactors (55)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKX7 NUP50
1
NUP50 [nucleoplasm]
(R-HSA-157740)
0.905
11
UniProt:Q92688 AN32B
0.837
9
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
0.759
5
UniProt:P20700 LMNB1
8
LMNB1 [nucleoplasm]
(R-HSA-264867)
LMNB1(1-231) [nuclear envelope]
(R-HSA-352244)
LMNB1(232-586) [nuclear envelope]
(R-HSA-352248)
LMNB1 [cytosol]
(R-HSA-2995384)
p-S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5228738)
p-S23, S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5229018)
LMNB1(2-586) [nuclear envelope]
(R-HSA-912402)
p-S23,S393-LMNB1 [nucleoplasm]
(R-HSA-8868341)
0.742
5
UniProt:O94782 USP1
3
USP1 [nucleoplasm]
(R-HSA-419546)
USP1(672-785) [nucleoplasm]
(R-HSA-5655474)
USP1(1-671) [nucleoplasm]
(R-HSA-5655484)
0.725
4
UniProt:P31345 PB2
0.683
3
UniProt:Q9BUI4 POLR3C
2
POLR3C [cytosol]
(R-HSA-1964448)
POLR3C [nucleoplasm]
(R-HSA-1964430)
0.666
4
UniProt:Q16594 TAF9
1
TAF9 [nucleoplasm]
(R-HSA-212452)
0.666
4
UniProt:P52298 NCBP2
2
NCBP2 [nucleoplasm]
(R-HSA-51463)
NCBP2 [cytosol]
(R-HSA-162458)
0.643
3
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.643
3
UniProt:Q9H814 PHAX
2
PHAX [cytosol]
(R-HSA-191804)
PHAX [nucleoplasm]
(R-HSA-191803)
0.643
4
UniProt:P49790 NUP153
1
NUP153 [nucleoplasm]
(R-HSA-157695)
0.643
3
UniProt:Q9HCK8 CHD8
1
CHD8 [nucleoplasm]
(R-HSA-3221598)
0.643
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.643
3
UniProt:O43148 RNMT
1
RNMT [nucleoplasm]
(R-HSA-77060)
0.643
4
UniProt:Q9NXV6 CARF
0.643
4
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.623
4
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.615
3
UniProt:Q8IUH3 RBM45
0.597
3
UniProt:Q9NX58 LYAR
0.564
2
UniProt:K9N643 ORF4B
0.564
3
UniProt:Q9HAZ1 CLK4
0.556
3
UniProt:Q9BQ69 MACD1
0.556
3
UniProt:Q9HAN9 NMNAT1
1
NMNAT1 [nucleoplasm]
(R-HSA-200484)
0.556
3
UniProt:P39687 ANP32A
1
ANP32A [nucleoplasm]
(R-HSA-450467)
0.547
2
UniProt:Q9H2P0 ADNP
0.527
2
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.527
2
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.527
2
UniProt:Q6P6C2 ALKBH5
1
ALKBH5 [nucleoplasm]
(R-HSA-8857700)
0.527
2
UniProt:Q8IY92 SLX4
1
SLX4 [nucleoplasm]
(R-HSA-5686477)
0.527
3
UniProt:O14776 TCERG1
1
TCERG1 [nucleoplasm]
(R-HSA-3246027)
0.527
2
UniProt:Q9BTL3 RAMAC
0.527
2
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.527
2
UniProt:Q9UQR1 ZN148
0.527
2
UniProt:Q68CP9 ARID2
1
ARID2 [nucleoplasm]
(R-HSA-5225613)
0.527
2
UniProt:Q9GZS1 POLR1E
1
POLR1E [nucleoplasm]
(R-HSA-5419294)
0.527
2
UniProt:Q05322 VP24
0.527
3
UniProt:Q86YP4 GATAD2A
1
GATAD2A [nucleoplasm]
(R-HSA-3702077)
0.527
2
UniProt:Q86TJ2 TADA2B
1
TADA2B [nucleoplasm]
(R-HSA-3322963)
0.527
2
UniProt:Q9H0D6 XRN2
2
XRN2 [nucleoplasm]
(R-HSA-6791205)
XRN2 [cytosol]
(R-HSA-391297)
0.527
2
UniProt:Q8N5I9 NOPC1
0.527
2
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.527
2
UniProt:Q9BTT0 AN32E
0.527
3
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.527
2
UniProt:O75528 TADA3
1
TADA3 [nucleoplasm]
(R-HSA-3322966)
0.527
2
UniProt:O60684 KPNA6
2
KPNA6 [nucleoplasm]
(R-HSA-9734665)
KPNA6 [cytosol]
(R-HSA-9734672)
0.527
2
UniProt:Q9Y2X3 NOP58
3
polySUMO2-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570460)
monoSUMO1-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570470)
NOP58 [nucleoplasm]
(R-HSA-4570488)
0.527
2
UniProt:Q13255 GRM1
2
GRM1(410-1194) [plasma membrane]
(R-HSA-9737058)
GRM1 [plasma membrane]
(R-HSA-420521)
0.524
2
UniProt:Q5TAQ9 DCAF8
1
DCAF8 [nucleoplasm]
(R-HSA-8955192)
0.524
2
UniProt:P03211 EBNA1
0.524
2
UniProt:P15918 RAG1
1
RAG1 [nucleoplasm]
(R-HSA-5692681)
0.508
2
UniProt:B4URF7 B4URF7
0.508
2
UniProt:Q9WMX2-PRO_0000037548
0.508
2
UniProt:Q8NHQ9 DDX55
0.483
2
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.483
2
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