B3GALT6 transfers Gal to the tetrasaccharide linker

Stable Identifier
R-HSA-1889978
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
A second galactose is added in the tetrasaccharide linker
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Beta-1,3-galactosyltransferase 6 (B3GALT6) transfers a second galactose to the tetrasaccharide linker. Although it can act on substrates with a terminal beta-linked galactose residue, it prefers the sequence galactose-beta-1,4-xylose (Bai et al. 2001). B3GALT6 requires manganese as a cofactor (Zhou et al. 1999).

Literature References
PubMed ID Title Journal Year
9892646 A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases

Zhou, D, Dinter, A, GutiƩrrez Gallego, R, Kamerling, JP, Vliegenthart, JF, Berger, EG, Hennet, T

Proc Natl Acad Sci U S A 1999
11551958 Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)

Bai, X, Zhou, D, Brown, JR, Crawford, BE, Hennet, T, Esko, JD

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
galactosylxylosylprotein 3-beta-galactosyltransferase activity of B3GALT6 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created