BLVRA:Zn2+, BLVRB reduce BV to BIL

Stable Identifier
R-HSA-189384
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Bilirubin (BIL) is the breakdown product of heme, causing death if allowed to accumulate in the blood. It is highly lipophilic and requires conjugation to become more water soluble to aid excretion. BIL is formed from the reduction of biliverdin (BV) by bilverdin reductases BLVRA and BLVRB (Cunningham et al. 2000, Fu et al. 2012, O'Brien et al. 2015).

Literature References
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
biliverdin reductase activity of BLVRA:Zn2+,BLVRB [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created