BLVRA:Zn2+, BLVRB reduce BV to BIL

Stable Identifier
R-HSA-189384
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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BLVRA:Zn2+, BLVRB reduce BV to BIL
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Bilirubin (BIL) is the breakdown product of heme, causing death if allowed to accumulate in the blood. It is highly lipophilic and requires conjugation to become more water soluble to aid excretion. BIL is formed from the reduction of biliverdin (BV) by bilverdin reductases BLVRA and BLVRB (Cunningham et al. 2000, Fu et al. 2012, O'Brien et al. 2015).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
biliverdin reductase activity of BLVRA:Zn2+,BLVRB [cytosol]
Physical Entity
BLVRA:Zn2+,BLVRB [cytosol]
Activity
biliverdin reductase activity (0004074)
Orthologous Events
BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Gallus gallus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Mus musculus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Rattus norvegicus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Sus scrofa)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Xenopus tropicalis)
Reviewed
Sassa, S  (2007-01-24)
Created
Jassal, B  (2006-11-20)