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HMOX2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-189391
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Heme oxygenase 2, HO2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of porphyrins (Homo sapiens)
Heme degradation (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30519 HMOX2
Gene Names
HMOX2, HO2
Chain
initiator methionine:1, chain:2-316
Reference Genes
BioGPS Gene:3163 HMOX2
COSMIC (genes):HMOX2 HMOX2
CTD Gene:3163 HMOX2
dbSNP Gene:3163 HMOX2
ENSEMBL:ENSG00000103415 HMOX2
ENSEMBL:ENSG00000277424 HMOX2
HGNC:5014 HMOX2
KEGG Gene (Homo sapiens):3163 HMOX2
Monarch:3163 HMOX2
NCBI Gene:3163 HMOX2
OMIM:141251 HMOX2
UCSC:P30519 HMOX2
Reference Transcript
RefSeq:NM_001127206.2 HMOX2
RefSeq:NM_001127205.1 HMOX2
RefSeq:NM_001286269.1 HMOX2
RefSeq:XM_017023196.1 HMOX2
RefSeq:NM_001286267.1 HMOX2
RefSeq:NM_001286271.1 HMOX2
RefSeq:XM_017023197.1 HMOX2
RefSeq:NM_001127204.1 HMOX2
RefSeq:NM_001286270.1 HMOX2
RefSeq:NM_001286268.1 HMOX2
RefSeq:NM_002134.3 HMOX2
Other Identifiers
0004590288
11729615_a_at
11755424_a_at
16815528
218120_PM_s_at
218120_s_at
218121_PM_at
218121_at
3163
3646200
3646202
3646204
3646205
3646206
3646207
3646211
3646212
3646213
3646214
3646216
3646217
3646219
3646220
3646221
3646222
3646223
37916_at
64632_at
7992987
A_14_P200412
A_23_P100501
A_24_P381945
GE80151
GO:0001666
GO:0003674
GO:0004392
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006788
GO:0006950
GO:0006979
GO:0008150
GO:0009056
GO:0016020
GO:0016491
GO:0020037
GO:0031410
GO:0034641
GO:0035579
GO:0042167
GO:0042592
GO:0043167
GO:0043226
GO:0043231
GO:0046872
GO:0055072
HMNXSV003058246
ILMN_1658807
PH_hs_0014732
PH_hs_0035751
S34389_at
TC16000131.hg
g416226_3p_a_at
g8051607_3p_at
Participates
as a member of
HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
HMOX2 [plasma membrane]
HMOX2 [specific granule membrane]
Inferred To
Hmox2 [endoplasmic reticulum membrane]
(Mus musculus)
Hmox2 [endoplasmic reticulum membrane]
(Rattus norvegicus)
hmox2 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
hmox2b [endoplasmic reticulum membrane]
(Danio rerio)
HMOX2 [endoplasmic reticulum membrane]
(Bos taurus)
HMOX2 [endoplasmic reticulum membrane]
(Canis familiaris)
HMOX2 [endoplasmic reticulum membrane]
(Gallus gallus)
HMOX2 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016878685.1
,
NP_001273200.1
,
NP_001273199.1
,
NP_001120678.1
,
NP_001120677.1
,
XP_016878686.1
,
NP_001273198.1
,
NP_001273196.1
,
NP_001120676.1
,
NP_001273197.1
,
NP_002125.3
Guide to Pharmacology - Targets
1442
OpenTargets
ENSG00000103415
HPA
ENSG00000103415-HMOX2
GeneCards
P30519
Ensembl
ENSP00000488769
,
ENSP00000478785
,
ENSG00000277424
,
ENSP00000488579
,
ENSG00000103415
,
ENST00000570646
,
ENST00000631677
,
ENST00000633319
,
ENSP00000391637
,
ENSP00000381595
,
ENST00000406590
,
ENSP00000483319
,
ENSP00000481295
,
ENSP00000481811
,
ENST00000458134
,
ENST00000620445
,
ENSP00000394103
,
ENSP00000460926
,
ENST00000621065
,
ENST00000622146
,
ENSP00000459214
,
ENST00000619913
,
ENST00000219700
,
ENST00000631540
,
ENST00000619528
,
ENSP00000484422
,
ENSP00000487673
,
ENSP00000219700
,
ENSP00000484423
,
ENST00000575120
,
ENSP00000484467
,
ENSP00000488880
,
ENST00000632458
,
ENST00000414777
,
ENST00000398595
,
ENST00000612525
,
ENSP00000385100
,
ENST00000615778
PRO
P30519
Pharos - Targets
P30519
PDB
2QPP
,
5UCA
,
2Q32
,
5UC9
,
5UC8
,
2RGZ
,
4WMH
HMDB Protein
HMDBP00151
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:Q14032 BAAT
2
BAAT [cytosol]
(R-HSA-159392)
BAAT [peroxisomal matrix]
(R-HSA-193517)
0.556
3
UniProt:P21579 SYT1
7
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q8IWU4 SLC30A8
1
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:O95470 SGPL1
1
PXLP-SGPL1 [endoplasmic reticulum membrane]
(R-HSA-428661)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9Y2X7 GIT1
2
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
GIT1 [cytosol]
(R-HSA-430326)
0.553
2
UniProt:P0DTC3 3a
9
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
0.527
2
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