PPO oxidises PPGEN9 to PRIN9

Stable Identifier
R-HSA-189423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
Synonyms
Oxidation of protoporphyrinogen IX to protoporphyrin IX
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PPO oxidises PPGEN9 to PRIN9
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Six electrons are oxidized in protophorphyrinogen IX (PPGEN9) to form the planar macrocycle protoporphyrin IX (PRIN9). This reaction is performed by the enzyme protoporphyrinogen oxidase (PPO). PPO functions as a homodimer containing one non-covalently-bound FAD. The protein resides on the outer surface of the inner mitochondrial membrane. PPO deficiency is associated with variegate porphyria in vivo.

Literature References
PubMed ID Title Journal Year
8771201 Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme

Dailey, TA, Dailey, HA

Protein Sci 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxygen-dependent protoporphyrinogen oxidase activity of 2xPPOX:FAD [mitochondrial intermembrane space]
Physical Entity
2xPPOX:FAD [mitochondrial intermembrane space]
Activity
oxygen-dependent protoporphyrinogen oxidase activity (0004729)
Orthologous Events
2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O (Gallus gallus)
PPO oxidises PPGEN9 to PRIN9 (Bos taurus)
PPO oxidises PPGEN9 to PRIN9 (Caenorhabditis elegans)
PPO oxidises PPGEN9 to PRIN9 (Canis familiaris)
PPO oxidises PPGEN9 to PRIN9 (Danio rerio)
PPO oxidises PPGEN9 to PRIN9 (Dictyostelium discoideum)
PPO oxidises PPGEN9 to PRIN9 (Drosophila melanogaster)
PPO oxidises PPGEN9 to PRIN9 (Mus musculus)
PPO oxidises PPGEN9 to PRIN9 (Plasmodium falciparum)
PPO oxidises PPGEN9 to PRIN9 (Rattus norvegicus)
PPO oxidises PPGEN9 to PRIN9 (Saccharomyces cerevisiae)
PPO oxidises PPGEN9 to PRIN9 (Schizosaccharomyces pombe)
PPO oxidises PPGEN9 to PRIN9 (Sus scrofa)
PPO oxidises PPGEN9 to PRIN9 (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
D'Eustachio, P  (2007-01-24)
Reviewed
Sassa, S  (2007-01-24)
Created
Jassal, B  (2006-11-20)