PPO oxidises PPGEN9 to PRIN9

Stable Identifier
R-HSA-189423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Oxidation of protoporphyrinogen IX to protoporphyrin IX
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Six electrons are oxidized in protophorphyrinogen IX (PPGEN9) to form the planar macrocycle protoporphyrin IX (PRIN9). This reaction is performed by the enzyme protoporphyrinogen oxidase (PPO). PPO functions as a homodimer containing one non-covalently-bound FAD. The protein resides on the outer surface of the inner mitochondrial membrane. PPO deficiency is associated with variegate porphyria in vivo.

Literature References
PubMed ID Title Journal Year
8771201 Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme

Dailey, TA, Dailey, HA

Protein Sci 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxygen-dependent protoporphyrinogen oxidase activity of 2xPPOX:FAD [mitochondrial intermembrane space]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created