Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ALAS1 [mitochondrial matrix]
Stable Identifier
R-HSA-189438
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
5-aminolevulinate synthase, non-specific, HEM1_HUMAN, 5-aminolevulinate synthase, non-specific, mitochondrial
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 [mitochondrial matrix] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13196 ALAS1
Gene Names
ALAS1, ALAS3, ALASH, OK/SW-cl.121
Chain
transit peptide:1-56, chain:57-640
Reference Genes
BioGPS Gene:211 ALAS1
COSMIC (genes):ALAS1 ALAS1
CTD Gene:211 ALAS1
dbSNP Gene:211 ALAS1
ENSEMBL:ENSG00000023330 ALAS1
HGNC:396 ALAS1
KEGG Gene (Homo sapiens):211 ALAS1
Monarch:211 ALAS1
NCBI Gene:211 ALAS1
OMIM:125290 ALAS1
Reference Transcript
RefSeq:NM_001304443.1 ALAS1
RefSeq:NM_199166.2 ALAS1
RefSeq:NM_001304444.1 ALAS1
RefSeq:NM_000688.5 ALAS1
Other Identifiers
0001450494
00260+2.3.1.37
00860+2.3.1.37
11719328_a_at
11719329_x_at
11733041_a_at
11750973_a_at
16941344
17498
205633_s_at
211
2623526
2623527
2623529
2623530
2623532
2623535
2623537
2623538
2623539
2623540
2623542
2623543
2623545
2623546
2623547
2623551
2623552
2623553
35860
37674_at
8080184
A_23_P57877
A_24_P191588
AAH11798
AAP94018
AB063322
AK312566
ALAS1
ALAS1-201
ALAS1-202
ALAS1-204
ALAS1-205
AY260745
BAB93514
BAG35461
BC011798
CAA39794
CAA68506
CAB017498
CCDS2847
CH471055
EAW65188
EAW65189
EAW65190
ENSG00000023330
ENSP00000309259
ENSP00000378416
ENSP00000417719
ENSP00000418779
ENST00000310271
ENST00000310271.6
ENST00000394965
ENST00000394965.6
ENST00000469224
ENST00000469224.5
ENST00000484952
ENST00000484952.5
EntrezGene:211
EntrezGene:ALAS1
g4502024_3p_a_at
GE59815
GE60231
GO:0003674
GO:0003824
GO:0003870
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006629
GO:0006778
GO:0006782
GO:0006783
GO:0007005
GO:0008150
GO:0009058
GO:0016740
GO:0016746
GO:0019216
GO:0030170
GO:0033014
GO:0034641
GO:0042802
GO:0043167
GO:0043226
GO:0051186
HGNC:396
HPA035860
ILMN_1700047
ILMN_1728309
ILMN_2385647
IPR001917
IPR004839
IPR010961
IPR015118
IPR015421
IPR015422
IPR015424
MIM:125290
NM_000688
NM_001304443
NM_001304444
NM_199166
NP_000679
NP_001291372
NP_001291373
NP_954635
PF00155
PF09029
PH_hs_0026670
PH_hs_0031344
Q5JAM2
TC03000329.hg
UPI0000001230
X56351
XM_011533477
XM_011533478
XM_017005873
XM_024453393
XP_011531779
XP_011531780
XP_016861362
XP_024309161
Y00451
Y00451_s_at
Participant Of
output
Expression of ALAS1
Other forms of this molecule
PXLP-ALAS1 [mitochondrial matrix]
Cross References
RefSeq
NP_954635.1
,
NP_001291372.1
,
NP_001291373.1
,
NP_000679.1
OpenTargets
ENSG00000023330
GeneCards
P13196
PRO
P13196
Orphanet
27149
HMDB Protein
HMDBP00022
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WTR2 DUS19
0.818
7
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.718
8
UniProt:Q9Y473 ZNF175
1
ZNF175 [nucleoplasm]
(R-HSA-975022)
0.696
5
UniProt:Q8WW24 TEKT4
0.696
5
UniProt:Q8TBZ8 ZNF564
1
ZNF564 [nucleoplasm]
(R-HSA-1973885)
0.696
5
UniProt:Q17RB0 RTL8B
0.696
5
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.696
5
UniProt:P63313 TYB10
0.696
5
UniProt:O60437 PPL
2
PPL [cornified envelope]
(R-HSA-8847709)
PPL [cytosol]
(R-HSA-6810850)
0.696
5
UniProt:Q9Y2S7 PDIP2
0.666
4
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.666
4
UniProt:P13196 ALAS1
2
ALAS1 [mitochondrial matrix]
(R-HSA-189438)
PXLP-ALAS1 [mitochondrial matrix]
(R-HSA-1022086)
0.621
3
IntAct:EBI-10198008 7120
0.556
3
IntAct:EBI-10197995 7116
0.556
3
UniProt:Q5W5X9 TTC23
0.556
3
UniProt:Q15560 TCEA2
0.556
3
UniProt:Q7Z614 SNX20
0.556
3
UniProt:Q8TD31-3 CCHCR1
0.556
3
UniProt:P53829 CAF40
0.556
3
UniProt:Q6PF15 KLH35
0.556
3
UniProt:Q9NWW7 CB042
0.556
3
UniProt:P48837 NUP57
0.556
3
UniProt:Q9NVN8 GNL3L
0.556
3
UniProt:Q68DK2-5 ZFYVE26
0.556
3
UniProt:P32902 RT04
0.556
3
UniProt:Q6P444 MTFR2
0.556
5
IntAct:EBI-10192162 7115
0.556
3
UniProt:P40099
1
MTHFS [cytosol]
(R-SCE-6801331)
0.556
3
UniProt:Q02821
2
KPNA2 [cytosol]
(R-SCE-205976)
KPNA1 [cytosol]
(R-SCE-180612)
0.556
3
UniProt:Q0P5Q0 Q0P5Q0
0.556
3
UniProt:Q9H788 SH24A
0.556
3
UniProt:Q4VC05 BCL7A
0.556
3
IntAct:EBI-10198019 84460
0.556
3
UniProt:Q8TCT0 CERK
1
CERK [plasma membrane]
(R-HSA-1631584)
0.556
3
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.556
3
UniProt:Q9Y2K6 USP20
1
USP20 [cytosol]
(R-HSA-5696946)
0.556
3
UniProt:Q9BVS5 TRMT61B
1
TRMT61B [mitochondrial matrix]
(R-HSA-6787512)
0.527
2
UniProt:A8MXD5 GRCR1
0.488
2
UniProt:C9JCN9 HSBPL
0.488
2
UniProt:Q9HAQ2 KIF9
1
KIF9 [cytosol]
(R-HSA-984616)
0.488
2
UniProt:P08579 SNRPB2
1
SNRPB2 [nucleoplasm]
(R-HSA-71960)
0.488
2
UniProt:O75564-2 O755642
0.488
2
UniProt:Q4G0R1 Q4G0R1
0.488
2
UniProt:P40123 CAP2
1
CAP2 [cytosol]
(R-HSA-428863)
0.488
2
IntAct:EBI-12336991 ZMAT1
0.488
2
UniProt:Q5TAP6 UTP14C
1
UTP14C [nucleoplasm]
(R-HSA-8867818)
0.488
2
UniProt:A8K0Z3 WASH1
0.488
2
UniProt:Q96CD0 FBXL8
1
FBXL8 [cytosol]
(R-HSA-8850912)
0.488
2
IntAct:EBI-18921357 TMSB4X
0.488
2
UniProt:Q765P7 MTSS2
0.488
2
UniProt:O75128 COBL
0.488
2
UniProt:Q96CN5 LRC45
0.488
2
UniProt:A0A0A0MR80 A0A0A0MR80
0.488
2
UniProt:Q8IYW5 RNF168
2
RNF168 [nucleoplasm]
(R-HSA-4551605)
SUMO1-RNF168 [nucleoplasm]
(R-HSA-4551750)
0.488
2
© 2019
Reactome