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FGF2(10-155) [extracellular region]
Stable Identifier
R-HSA-189898
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FGF2, Fibroblast growth factor-2, Heparin-binding growth factor 2, FGF2_HUMAN, Basic fibroblast growth factor, bFGF
Locations in the PathwayBrowser for interactor UniProt:P11362
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of intermediate mesoderm (Homo sapiens)
Expression of LHX1 in intermediate mesoderm (Homo sapiens)
FGF2(10-155) [extracellular region] (Homo sapiens)
Expression of PAX2 in intermediate mesoderm (Homo sapiens)
FGF2(10-155) [extracellular region] (Homo sapiens)
Kidney development (Homo sapiens)
Formation of the nephric duct (Homo sapiens)
Expression of PAX2 in intermediate mesoderm (Homo sapiens)
FGF2(10-155) [extracellular region] (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (Homo sapiens)
Expression of FGF2 (Homo sapiens)
FGF2(10-155) [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)
FGF2(10-155) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09038 FGF2
Gene Names
FGF2, FGFB
Chain
propeptide:1-142, chain:143-288
Reference Genes
BioGPS Gene:2247 FGF2
COSMIC (genes):FGF2 FGF2
CTD Gene:2247 FGF2
dbSNP Gene:2247 FGF2
ENSEMBL:ENSG00000138685 FGF2
ENSEMBL_homo_sapiens_GENE:ENSG00000138685.18 FGF2
HGNC:3676 FGF2
KEGG Gene (Homo sapiens):2247 FGF2
Monarch:2247 FGF2
NCBI Gene:2247 FGF2
OMIM:134920 FGF2
UCSC:P09038 FGF2
Reference Transcript
RefSeq:NM_002006.4 FGF2
Other Identifiers
11725039_at
11725040_at
11725041_at
1593_at
16970404
1828_s_at
204421_PM_s_at
204421_s_at
204422_PM_s_at
204422_s_at
2247
2742110
2742111
2742112
2742113
2742114
2742121
2742125
2742126
2742127
2742128
2742129
41806_at
8097256
A_14_P107501
A_14_P108631
A_23_P218918
A_33_P3379886
A_33_P3419696
GE57510
GO:0001525
GO:0001649
GO:0001658
GO:0001759
GO:0001934
GO:0001935
GO:0001938
GO:0002042
GO:0002052
GO:0005104
GO:0005125
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0006351
GO:0006355
GO:0006366
GO:0006935
GO:0007165
GO:0007265
GO:0007399
GO:0007405
GO:0008083
GO:0008201
GO:0008283
GO:0008284
GO:0008285
GO:0008543
GO:0009792
GO:0009887
GO:0010001
GO:0010595
GO:0010628
GO:0010629
GO:0010764
GO:0012501
GO:0014843
GO:0019956
GO:0021762
GO:0021930
GO:0021940
GO:0023052
GO:0030154
GO:0030214
GO:0030324
GO:0030374
GO:0036211
GO:0038001
GO:0040037
GO:0042056
GO:0042060
GO:0042491
GO:0042660
GO:0042802
GO:0043226
GO:0043406
GO:0043410
GO:0043491
GO:0043536
GO:0043537
GO:0043542
GO:0045609
GO:0045669
GO:0045765
GO:0045766
GO:0045893
GO:0045944
GO:0046668
GO:0048018
GO:0048598
GO:0048661
GO:0048678
GO:0048856
GO:0048863
GO:0048864
GO:0048870
GO:0050673
GO:0050679
GO:0050918
GO:0051209
GO:0051726
GO:0051781
GO:0051897
GO:0055065
GO:0055085
GO:0060045
GO:0060070
GO:0060128
GO:0060129
GO:0060563
GO:0060591
GO:0060644
GO:0060978
GO:0061045
GO:0070371
GO:0070374
GO:0071260
GO:0072089
GO:0090049
GO:0090050
GO:0090263
GO:0090722
GO:0098772
GO:0140110
GO:1901135
GO:1902748
GO:1902895
GO:1902913
GO:1903587
GO:1903672
GO:1904707
GO:1904977
GO:1905278
GO:1905564
GO:2000544
GO:2000546
GO:2000573
GO:2000647
GO:2000648
GO:2000738
GO:2001028
HMNXSV003036302
ILMN_1744693
ILMN_2105919
J04513_at
M27968_s_at
PH_hs_0028108
TC04000630.hg
TC04002187.hg
g182562_3p_s_at
g4503698_3p_s_at
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
FGF1,2 [extracellular region] (Homo sapiens)
FGFR2b mutant-binding FGFs [extracellular region] (Homo sapiens)
FGF2,7,10,22 [extracellular region] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGFR1b-binding FGFs [extracellular region] (Homo sapiens)
FGFR1c-binding FGFs [extracellular region] (Homo sapiens)
FGFR2c-binding FGFs [extracellular region] (Homo sapiens)
FGFR3c-binding FGFs [extracellular region] (Homo sapiens)
as a component of
SDC1,2,4,(3):FGF2 [plasma membrane] (Homo sapiens)
FGF2:TGFBR3 [plasma membrane] (Homo sapiens)
as an input of
Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)
as a candidate of
FGFRL1-binding FGFs [extracellular region] (Homo sapiens)
as an output of
Expression of FGF2 (Homo sapiens)
This entity regulates
Positively
Expression of LHX1 in intermediate mesoderm
(Homo sapiens)
Expression of PAX2 in intermediate mesoderm
(Homo sapiens)
Inferred To
FGF2 [extracellular region]
(Sus scrofa)
FGF2(10-155) [extracellular region]
(Bos taurus)
FGF2(10-155) [extracellular region]
(Canis familiaris)
FGF2(10-155) [extracellular region]
(Danio rerio)
FGF2(10-155) [extracellular region]
(Gallus gallus)
FGF2(10-155) [extracellular region]
(Mus musculus)
FGF2(10-155) [extracellular region]
(Rattus norvegicus)
let-756 [extracellular region]
(Caenorhabditis elegans)
fgf2 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001997.5
OpenTargets
ENSG00000138685
ZINC - Substances
FGF2_HUMAN
ZINC target
P09038
PRO
P09038
PDB
2FGF
,
5X1O
,
6L4O
,
1CVS
,
1EV2
,
4OEF
,
1II4
,
4OEE
,
1BLD
,
1BFF
,
1BFB
,
2M49
,
4FGF
,
2BFH
,
1BAS
,
1FGA
,
1BFC
,
1BLA
,
4OEG
,
1IIL
,
1FQ9
,
1BFG
GeneCards
P09038
HPA
ENSG00000138685-FGF2
Ensembl
ENSP00000264498
,
ENSP00000494222
,
ENSP00000477134
,
ENST00000264498
,
ENST00000608478
,
ENSG00000138685
,
ENST00000644866
Pharos - Targets
P09038
ZINC - Predictions - Purchasable
FGF2_HUMAN
Orphanet
24535
HMDB Protein
HMDBP02107
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.912
9
UniProt:P26022 PTX3
3
PTX3 [tertiary granule lumen]
(R-HSA-6800932)
PTX3 [extracellular region]
(R-HSA-6806290)
PTX3 [specific granule lumen]
(R-HSA-6799620)
0.788
16
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
FGFR2 K660M [plasma membrane]
(R-HSA-1637902)
FGFR2 K660E [plasma membrane]
(R-HSA-1637900)
FGFR2 S267P [plasma membrane]
(R-HSA-1637920)
FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-1637908)
FGFR2 W290C [plasma membrane]
(R-HSA-1637929)
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853134)
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853146)
0.713
4
ChEBI:28304 HEPARIN
0.683
3
UniProt:Q14512 FGFBP1
1
FGFBP1 [extracellular region]
(R-HSA-5656040)
0.618
3
UniProt:P98066 TNFAIP6
3
TNFAIP6 [tertiary granule lumen]
(R-HSA-6803341)
TNFAIP6 [extracellular region]
(R-HSA-6803348)
TNFAIP6 [ficolin-1-rich granule lumen]
(R-HSA-6803311)
0.611
3
UniProt:P21802-1 FGFR2
20
FGFR2c S252W [plasma membrane]
(R-HSA-2011852)
FGFR2c P253R [plasma membrane]
(R-HSA-1637916)
FGFR2c A315S [plasma membrane]
(R-HSA-2071931)
FGFR2c A314S [plasma membrane]
(R-HSA-2071928)
FGFR2c A314D [plasma membrane]
(R-HSA-1637888)
FGFR2c A315T [plasma membrane]
(R-HSA-1637889)
FGFR2c W290G [plasma membrane]
(R-HSA-2029883)
FGFR2c Y375C [plasma membrane]
(R-HSA-2029881)
FGFR2c S372C [plasma membrane]
(R-HSA-2029886)
p-8Y-FGFR2c S252W [plasma membrane]
(R-HSA-2011879)
p-8Y-FGFR2c P253R [plasma membrane]
(R-HSA-2011880)
p-8Y-FGFR2c A315S mutant [plasma membrane]
(R-HSA-2071942)
p-8Y-FGFR2c A314S [plasma membrane]
(R-HSA-2071944)
p-8Y-FGFR2c A314D [plasma membrane]
(R-HSA-2071946)
p-8Y-FGFR2c A315T [plasma membrane]
(R-HSA-2071940)
p-8Y-FGFR2c W290G [plasma membrane]
(R-HSA-2029862)
p-8Y-FGFR2c S372C [plasma membrane]
(R-HSA-2029865)
p-8Y-FGFR2c Y375C [plasma membrane]
(R-HSA-2029861)
FGFR2c long [plasma membrane]
(R-HSA-189920)
p-8Y-FGFR2c long [plasma membrane]
(R-HSA-190416)
0.558
2
UniProt:P11362-7 FGFR1
0.544
2
UniProt:O15530 PDPK1
2
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
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