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FGFR4 [plasma membrane]
Stable Identifier
R-HSA-189921
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Fibroblast growth factor receptor 4, FGR4_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P05230 FGF1
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
FGFR4 ligand binding and activation (Homo sapiens)
FGFR4 binds to FGF (Homo sapiens)
FGFR4 [plasma membrane] (Homo sapiens)
betaKlotho-mediated ligand binding (Homo sapiens)
FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
FGFR4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22455 FGFR4
Gene Names
FGFR4, JTK2, TKF
Chain
signal peptide:1-21, chain:22-802
Reference Genes
BioGPS Gene:2264 FGFR4
COSMIC (genes):FGFR4 FGFR4
CTD Gene:2264 FGFR4
dbSNP Gene:2264 FGFR4
ENSEMBL:ENSG00000160867 FGFR4
ENSEMBL_homo_sapiens_GENE:ENSG00000160867.15 FGFR4
HGNC:3691 FGFR4
KEGG Gene (Homo sapiens):2264 FGFR4
Monarch:2264 FGFR4
NCBI Gene:2264 FGFR4
OMIM:134935 FGFR4
UCSC:P22455 FGFR4
Reference Transcript
RefSeq:NM_002011.4 FGFR4
RefSeq:XM_005265838.3 FGFR4
RefSeq:NM_213647.2 FGFR4
RefSeq:NM_001291980.1 FGFR4
RefSeq:NM_022963.3 FGFR4
Other Identifiers
11735873_a_at
11740240_a_at
11744657_x_at
11752172_a_at
11753528_a_at
11757181_x_at
1291_s_at
1554962_PM_a_at
1554962_a_at
16992957
204579_PM_at
204579_at
211237_PM_s_at
211237_s_at
2264
2842912
2842913
2842914
2842915
2842916
2842918
2842920
2842922
2842923
2842924
2842926
2842928
2842930
2842931
2842932
2842933
2842934
2842935
2842936
2842938
2842939
2842941
2842943
2842944
8110265
A_14_P131381
A_23_P92754
GO:0000166
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005768
GO:0005783
GO:0005794
GO:0005886
GO:0005911
GO:0006468
GO:0006629
GO:0007169
GO:0008201
GO:0008284
GO:0008543
GO:0010628
GO:0010715
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0019216
GO:0023052
GO:0030133
GO:0030198
GO:0031410
GO:0036211
GO:0042593
GO:0042632
GO:0043085
GO:0043226
GO:0043235
GO:0045862
GO:0046777
GO:0048870
GO:0055062
GO:0060089
GO:0070374
GO:0070857
GO:0140096
GO:2000573
HMNXSV003054104
ILMN_1730355
ILMN_2241412
ILMN_2410713
L03840_s_at
PH_hs_0010000
TC05001010.hg
g13112051_3p_at
g6739817_3p_a_at
Participates
as an input of
FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
FGFR4 binds to FGF (Homo sapiens)
as a component of
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
FGFR4 homodimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
FGFR4 Y367C [plasma membrane]
FGFR4 N535K [plasma membrane]
FGFR4 V550E [plasma membrane]
FGFR4 V550L [plasma membrane]
FGFR4 N535D [plasma membrane]
p-5Y-FGFR4 V550E [plasma membrane]
p-5Y-FGFR4 N535K [plasma membrane]
p-5Y-FGFR4 V550L [plasma membrane]
p-5Y-FGFR4 N535D [plasma membrane]
p5Y-FGFR4 Y367C mutant [plasma membrane]
p-5Y-FGFR4 [plasma membrane]
Inferred To
FGFR4 [plasma membrane]
(Bos taurus)
FGFR4 [plasma membrane]
(Caenorhabditis elegans)
FGFR4 [plasma membrane]
(Canis familiaris)
FGFR4 [plasma membrane]
(Danio rerio)
FGFR4 [plasma membrane]
(Drosophila melanogaster)
FGFR4 [plasma membrane]
(Gallus gallus)
FGFR4 [plasma membrane]
(Mus musculus)
FGFR4 [plasma membrane]
(Rattus norvegicus)
FGFR4 [plasma membrane]
(Sus scrofa)
FGFR4 [plasma membrane]
(Xenopus tropicalis)
Homologues of FGFR4 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001278909.1
,
NP_002002.3
,
NP_998812.1
,
XP_005265895.1
,
NP_075252.2
ZINC - World Drugs
FGFR4_HUMAN
Guide to Pharmacology - Targets
1811
OpenTargets
ENSG00000160867
ZINC - FDA approved
FGFR4_HUMAN
ZINC - Substances
FGFR4_HUMAN
ZINC - Biogenic
FGFR4_HUMAN
ZINC target
P22455
PRO
P22455
PDB
6IUO
,
4XCU
,
7WCW
,
4QQJ
,
6JPE
,
6NVK
,
5NUD
,
6JPJ
,
7VJL
,
7YBP
,
4TYJ
,
5XFF
,
7YSW
,
7DTZ
,
6V9C
,
7F3M
,
5JKG
,
4QQC
,
4R6V
,
7YBO
,
6YI8
,
6NVJ
,
4QRC
,
4TYG
,
7WCT
,
7V29
,
4TYI
,
4UXQ
,
7TYD
,
7YC3
,
6J6Y
,
4TYE
,
6NVI
,
5XFJ
,
7YC1
,
7YBX
,
5NWZ
,
6NVG
,
6IUP
,
6NVH
,
4QQ5
,
7N1J
,
4QQT
,
7WCX
ZINC - Investigational
FGFR4_HUMAN
GeneCards
P22455
HPA
ENSG00000160867-FGFR4
Ensembl
ENST00000393637
,
ENSP00000292408
,
ENSP00000377254
,
ENST00000502906
,
ENSP00000424960
,
ENST00000292408
,
ENSG00000160867
Pharos - Targets
P22455
ZINC - Predictions - Purchasable
FGFR4_HUMAN
Orphanet
24538
HMDB Protein
HMDBP01234
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.539
3
UniProt:Q3MIR4 CC50B
0.527
2
UniProt:Q96G30 MRAP2
0.527
2
UniProt:P55899 FCGRN
0.527
2
UniProt:Q6ZMH5 SLC39A5
1
SLC39A5 [plasma membrane]
(R-HSA-442360)
0.527
2
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.519
2
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.499
2
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.483
2
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