FGFR3 ligand binding and activation

Stable Identifier
R-HSA-190239
Type
Pathway
Species
Homo sapiens
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FGFR3 is a receptor tyrosine kinase of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Somatically, some of the same activating mutations are associated with hypochondroplasia, multiple myeloma, and cervical and vesical carcinoma.

Literature References
PubMed ID Title Journal Year
15748888 Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

L'Hote, CG, Knowles, MA

Exp Cell Res 2005
16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Zhang, X, Ibrahimi, OA, Olsen, SK, Umemori, H, Mohammadi, M, Ornitz, DM

J Biol Chem 2006
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK

J Biol Chem 1997
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