FGFR1c and Klotho ligand binding and activation

Stable Identifier
R-HSA-190374
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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FGFR1c and Klotho ligand binding and activation
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FGF23 is a member of the endocrine subfamily of FGFs. It is produced in bone tissue and regulates kidney functions. Klotho is essential for endogenous FGF23 function as it converts FGFR1c into a specific FGF23 receptor.
Literature References
PubMed ID Title Journal Year
17086194 Klotho converts canonical FGF receptor into a specific receptor for FGF23

Yamazaki, Y, Fukumoto, S, Shimada, T, Iijima, K, Urakawa, I, Okawa, K, Fujita, T, Yameshita, T, Hasegawa, H

Nature 2006
16436388 Regulation of fibroblast growth factor-23 signaling by klotho

Kuro-O, M, Baum, MG, Miyoshi, M, Ogawa, Y, Schiavi, S, Nandi, A, Kurosu, H, Rosenblatt, KP, Yamamoto, M, Hu, MC, Moe, OW

J Biol Chem 2006
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Event Information
Go Biological Process
fibroblast growth factor receptor signaling pathway (0008543)
Orthologous Events
FGFR1c and Klotho ligand binding and activation (Bos taurus)
FGFR1c and Klotho ligand binding and activation (Caenorhabditis elegans)
FGFR1c and Klotho ligand binding and activation (Canis familiaris)
FGFR1c and Klotho ligand binding and activation (Danio rerio)
FGFR1c and Klotho ligand binding and activation (Drosophila melanogaster)
FGFR1c and Klotho ligand binding and activation (Gallus gallus)
FGFR1c and Klotho ligand binding and activation (Mus musculus)
FGFR1c and Klotho ligand binding and activation (Rattus norvegicus)
FGFR1c and Klotho ligand binding and activation (Sus scrofa)
FGFR1c and Klotho ligand binding and activation (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Created
de Bono, B  (2007-01-02)
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