Reactome | GJA5 [endoplasmic reticulum membrane]

GJA5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-190648

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Connexin 40

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction assembly (Homo sapiens)
        
        Connexin synthesis (generic) (Homo sapiens)
        
        Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)
        
        GJA5 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36382 GJA5

Gene Names

GJA5

Chain

chain:1-358

Reference Genes

BioGPS Gene:2702 GJA5

COSMIC (genes):GJA5 GJA5

CTD Gene:2702 GJA5

dbSNP Gene:2702 GJA5

ENSEMBL:ENSG00000265107 GJA5

HGNC:4279 GJA5

KEGG Gene (Homo sapiens):2702 GJA5

Monarch:2702 GJA5

NCBI Gene:2702 GJA5

OMIM:121013 GJA5

UCSC:P36382 GJA5

Reference Transcript

Other Identifiers

0000460358

0000730717

0006650333

11741706_a_at

11743924_a_at

16692362

2074_at

214466_at

226701_at

2433445

2433446

2433447

2433448

2433449

2433450

2433451

2433452

2433453

2433457

2702

64929_at

7919340

A_23_P371729

GE88385

GE88386

GO:0001501

GO:0001525

GO:0001568

GO:0003013

GO:0003071

GO:0003073

GO:0003105

GO:0003151

GO:0003158

GO:0003161

GO:0003174

GO:0003193

GO:0003281

GO:0003283

GO:0003284

GO:0003294

GO:0003674

GO:0005243

GO:0005515

GO:0005575

GO:0005886

GO:0005887

GO:0005921

GO:0005922

GO:0006810

GO:0006813

GO:0007154

GO:0007267

GO:0007507

GO:0008150

GO:0009790

GO:0010643

GO:0010644

GO:0010649

GO:0010652

GO:0014704

GO:0015031

GO:0016020

GO:0016021

GO:0016264

GO:0022607

GO:0022857

GO:0030054

GO:0030326

GO:0032991

GO:0034330

GO:0035050

GO:0035922

GO:0042592

GO:0042995

GO:0045776

GO:0045907

GO:0048646

GO:0048844

GO:0048856

GO:0055077

GO:0055085

GO:0055117

GO:0060307

GO:0060371

GO:0060373

GO:0060412

GO:0060413

GO:0061337

GO:0071253

GO:0086005

GO:0086015

GO:0086020

GO:0086021

GO:0086044

GO:0086053

GO:0086054

GO:0086055

GO:0086064

GO:0086065

GO:0086067

GO:0086075

GO:0086076

GO:0086077

GO:0086078

GO:0086079

GO:0086091

GO:0097718

GO:0097746

GO:0097755

GO:0098904

GO:0098905

GO:0098906

GO:0098910

GO:1900133

GO:1900825

GO:1990029

Hs.247926.0.S1_3p_at

Hs.7473.0.A1_3p_at

ILMN_1702972

ILMN_1703381

ILMN_1722753

PH_hs_0026184

TC01003129.hg

U03486_at

Participant Of

hasCandidate

Monomeric connexin protein [endoplasmic reticulum membrane]

Inferred To

GJA5 [endoplasmic reticulum membrane] (Canis familiaris)

GJA5 [endoplasmic reticulum membrane] (Sus scrofa)

plk4 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Gja5 [endoplasmic reticulum membrane] (Mus musculus)

Gja5 [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_016856533.1, NP_859054.1, XP_005273008.1, NP_005257.2

OpenTargets

ENSG00000265107

HPA

ENSG00000265107-GJA5

GeneCards

P36382

Ensembl

ENSP00000463851, ENSG00000265107, ENST00000621517, ENST00000579774, ENSP00000484552

PRO

P36382

Orphanet

16800

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P29033 GJB2	3	GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614) GJB2 [plasma membrane] (R-HSA-53211)	0.556	3
UniProt:Q9UKG4 SLC13A4	1	SLC13A4 [plasma membrane] (R-HSA-433098)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714) SLC30A2 [endosome membrane] (R-HSA-435363)	0.556	3
UniProt:P24593 IGFBP5	5	p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3