Gap junction assembly

Stable Identifier
R-HSA-190861
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The assembly of gap junctions involves (1) synthesis of connexin polypeptides at endoplasmic reticulum membranes, (2) oligomerization into homomeric- and heteromeric gap junction connexons (hemi-channels), (3) passage through the Golgi stacks, (4) intracellular storage within Trans Golgi membranes, (5) trafficking along microtubules, (6) insertion of connexons into the plasma membrane, (7) lateral diffusion of connexons in the plasma membrane, (8) aggregation of individual gap junction channels into plaques, and (9) stabilization of peripheral microtubule plus-ends by binding to Cx43-based gap junctions (see Segretain and Falk, 2004.)

Literature References
PubMed ID Title Journal Year
8665925 Connections with connexins: the molecular basis of direct intercellular signaling

Bruzzone, R, White, TW, Paul, DL

Eur J Biochem 1996
15033576 Regulation of connexin biosynthesis, assembly, gap junction formation, and removal

Segretain, D, Falk, MM

Biochim Biophys Acta 2004
Participants
Participant Of
Event Information
Go Biological Process
Orthologous Events
Authored
Created