Gap junction degradation

Stable Identifier
R-HSA-190873
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The half-life of Cx is very short (1 to 5h) compared to other junctional proteins (Laird et al., 1995 ; Fallon and Goudenough, 1981). Connexins are targeted for degradation by the proteasome and the lysosome. Degradation appears to involve the phosphorylation of Connexins as well as their interactions with other proteins (Piehl et al., 2007).

Literature References
PubMed ID Title Journal Year
8522583 Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells

Laird, DW, Castillo, M, Kasprzak, L

J Cell Biol 1995
17108328 Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process

Piehl, M, Lehmann, C, Gumpert, A, Denizot, JP, Segretain, D, Falk, MM

Mol Biol Cell 2007
Participants
Participant Of
Orthologous Events
Authored