ITCH ubiquitinates DTX

Stable Identifier
R-HSA-1912357
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ITCH ubiquitinates DTX
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ITCH ubiquitinates DTX, targeting it for degradation.
Literature References
PubMed ID Title Journal Year
17028573 Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

Brou, C, Israel, A, Chastagner, P

EMBO Rep 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of DTX:ITCH [cytosol]

Physical Entity
DTX:ITCH [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
ITCH ubiquitinates DTX (Bos taurus)
ITCH ubiquitinates DTX (Canis familiaris)
ITCH ubiquitinates DTX (Danio rerio)
ITCH ubiquitinates DTX (Drosophila melanogaster)
ITCH ubiquitinates DTX (Gallus gallus)
ITCH ubiquitinates DTX (Mus musculus)
ITCH ubiquitinates DTX (Rattus norvegicus)
ITCH ubiquitinates DTX (Sus scrofa)
ITCH ubiquitinates DTX (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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