Ubiquitination of NOTCH1 by ITCH in the absence of ligand

Stable Identifier
R-HSA-1912386
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ITCH, recruited to NOTCH1 indirectly through association with NUMB, ubiquitinates NOTCH1 and targets it for degradation.

Literature References
PubMed ID Title Journal Year
19567869 Numb regulates post-endocytic trafficking and degradation of Notch1

McGill, MA, Dho, SE, Weinmaster, G, McGlade, CJ

J Biol Chem 2009
18628966 AIP4/Itch regulates Notch receptor degradation in the absence of ligand

Chastagner, P, Israel, A, Brou, C

PLoS One 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of NOTCH1:NUMB:ITCH [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created