MAML in complex with NICD1 recruits CDK8

Stable Identifier
R-HSA-1912393
Type
Reaction [binding]
Species
Homo sapiens
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After NOTCH1 coactivator complex is assembled on a NOTCH-target promoter, MAML (mastermind-like) recruits CDK8 in complex with cyclin C (CDK:CCNC) (Fryer et al. 2004).

Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
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