NOTCH1 binds DNER

Stable Identifier
R-HSA-1912398
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DNER is a transmembrane protein specifically expressed in dendrites and cell bodies of postmitotic neurons. DNER has ten extracellular EGF repeats highly homologous to EGF repeats of Notch and Delta proteins, but does not contain a typical DSL domain. DNER binds NOTCH1 and this interaction involves the first and second EGF repeat of DNER. Activation of NOTCH1 signaling by DNER requires the presence of deltex (DTX1, DTX2 and/or DTX4). The interaction of DNER and NOTCH may be playing an important role in the development of the central nervous system by influencing the differentiation of astrocytes, based on mouse studies.

Literature References
PubMed ID Title Journal Year
15965470 DNER acts as a neuron-specific Notch ligand during Bergmann glial development

Eiraku, M, Tohgo, A, Ono, K, Kaneko, M, Fujishima, K, Hirano, T, Kengaku, M

Nat Neurosci 2005
Participants
Participant Of
Inferred From
Authored
Reviewed
Created