NOTCH2 mRNA translation controlled by miRNAs

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R-HSA-1912413
Type
Reaction [omitted]
Species
Homo sapiens
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Translation of NOTCH2 mRNA is negatively regulated by miR-34 microRNAs (Li et al. 2009). miR-34 miRNAs bind and cause degradation of NOTCH2 mRNA, resulting in decreased level of NOTCH2 protein product.

Literature References
PubMed ID Title Journal Year
19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

Li, Y, Guessous, F, Zhang, Y, DiPierro, C, Kefas, B, Johnson, E, Marcinkiewicz, L, Jiang, J, Yang, Y, Schmittgen, TD, Lopes, B, Schiff, D, Purow, B, Abounader, R

Cancer Res 2009
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