NOTCH2 mRNA translation controlled by miRNAs

Stable Identifier
R-HSA-1912413
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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NOTCH2 mRNA translation controlled by miRNAs
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Translation of NOTCH2 mRNA is negatively regulated by miR-34 microRNAs (Li et al. 2009). miR-34 miRNAs bind and cause degradation of NOTCH2 mRNA, resulting in decreased level of NOTCH2 protein product.
Literature References
PubMed ID Title Journal Year
19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

Guessous, F, DiPierro, C, Kefas, B, Li, Y, Schiff, D, Johnson, E, Jiang, J, Purow, B, Lopes, B, Zhang, Y, Marcinkiewicz, L, Abounader, R, Yang, Y, Schmittgen, TD

Cancer Res 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NOTCH2 mRNA:miR-34 RISC [cytosol] (Homo sapiens)
Active Unit
miR-34 RISC [cytosol]
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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