NOTCH3 gene transcription

Stable Identifier
R-HSA-1912415
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH3 gene transcription
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The NOTCH3 gene maps to human chromosome 19. NOTCH3 transcript is ubiquitously expressed in fetal and adult human tissues. Mutations in NOTCH3 are found in cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an autosomal dominant progressive disorder of small arterial vessels of the brain characterized by migraines, strokes, and white matter lesions, with the onset in early adulthood (Joutel et al. 1996).

NOTCH3 gene transcription is stimulated by the NOTCH3 coactivator complex but it is not known whether this effect is direct, or indirect (Liu et al. 2009).

NOTCH3 gene transcription is directly stimulated by the NOTCH1 coactivator complex and NOTCH1-mediated regulation of NOTCH3 is involved in differentiation of esophageal squamous cells (Ohashi et al. 2009).

NOTCH3 transcription is directly stimulated by transcription factor ELF3, activated by PRKCI (protein kinase C iota)-mediated phosphorylation downstream of KRAS signaling. The PRKCI-ELF3-NOTCH3 signaling controls the tumor-initiating cell phenotype in KRAS-mediated lung adenocarcinoma (Ali et al. 2016).

Literature References
PubMed ID Title Journal Year
26977885 Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Jamieson, L, Justilien, V, Murray, NR, Ali, SA, Fields, AP

Cancer Cell 2016
20801121 NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network

Katz, JP, Kalman, RA, Nakagawa, M, Klein-Szanto, AJ, Yashiro-Ohtani, Y, Wu, L, Nakagawa, H, Pear, WS, Seykora, JT, Herlyn, M, Ohashi, S, Natsuizaka, M, Diehl, JA

Gastroenterology 2010
8878478 Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

Cabanis, EA, Chabriat, H, Corpechot, C, Cruaud, C, Maréchal, E, Cécillion, M, Domenga, V, Joutel, A, Ducros, A, Maciazek, J, Mouton, P, Ruchoux, MM, Weissenbach, J, Tournier-Lasserve, E, Vahedi, K, Vayssiere, C, Alamowitch, S, Bach, JF, Bousser, MG

Nature 1996
19150886 NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1

Liu, H, Kennard, S, Lilly, B

Circ. Res. 2009
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of Notch signaling pathway (0045747)
This event is regulated
Positively by
Regulator
NOTCH1 coactivator complex:NOTCH3 gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH1 Coactivator Complex [nucleoplasm]
Regulator
p-S68-ELF3:NOTCH3 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S68-ELF3 [nucleoplasm]
Regulator
NOTCH3 coactivator complex [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2017-10-30)
Haw, R  (2012-05-17)
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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