Addition of isopentenyl pyrophosphate to DMAPP

Stable Identifier
R-HSA-191322
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate to DMAPP: farnesyl pyrophosphate synthase (FPPS) and geranylgeranyl pyrophosphate synthetase (GGPPS) (Kavanaugh et al, 2006).

Literature References
PubMed ID Title Journal Year
16684881 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

Kavanagh, KL, Guo, K, Dunford, JE, Wu, X, Knapp, S, Ebetino, FH, Rogers, MJ, Russell, RG, Oppermann, U

Proc Natl Acad Sci U S A 2006
9741684 Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression

Ericsson, J, Greene, JM, Carter, KC, Shell, BK, Duan, DR, Florence, C, Edwards, PA

J Lipid Res 1998
10026212 Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.

Kuzuguchi, T, Morita, Y, Sagami, I, Sagami, H, Ogura, K

J Biol Chem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dimethylallyltranstransferase activity of FDPS,GGPS1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created