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HMGCS1 [cytosol]
Stable Identifier
R-HSA-191329
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Hydroxymethylglutaryl-CoA synthase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)
HMGCS1 [cytosol] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
HMGCS1 [cytosol] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
HMGCS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01581 HMGCS1
Gene Names
HMGCS1, HMGCS
Chain
chain:1-520
Reference Genes
BioGPS Gene:3157 HMGCS1
COSMIC (genes):HMGCS1 HMGCS1
CTD Gene:3157 HMGCS1
dbSNP Gene:3157 HMGCS1
ENSEMBL:ENSG00000112972 HMGCS1
HGNC:5007 HMGCS1
KEGG:hsa:3157 HMGCS1
Monarch:3157 HMGCS1
NCBI Gene:3157 HMGCS1
OMIM:142940 HMGCS1
UCSC:Q01581 HMGCS1
Reference Transcript
RefSeq:NM_001324220.1 HMGCS1
RefSeq:NM_001098272.2 HMGCS1
RefSeq:NM_002130.7 HMGCS1
RefSeq:NM_001324223.1 HMGCS1
RefSeq:NM_001324224.1 HMGCS1
RefSeq:NM_001324222.1 HMGCS1
RefSeq:NM_001324219.1 HMGCS1
RefSeq:NM_001330663.1 HMGCS1
Other Identifiers
11716987_a_at
11754918_s_at
16995890
205822_PM_s_at
205822_s_at
221750_PM_at
221750_at
2387715
2855498
2855500
2855502
2855503
2855504
2855505
2855506
2855507
2855508
2855509
2855512
2855513
2855514
2855515
2855516
2855517
2855518
2855519
2855520
2855522
2855523
2855524
2855525
2855526
2855527
2855528
2855529
2855531
2855535
3157
34517_at
54968_at
78228_s_at
8111941
89646_r_at
A_23_P133263
A_24_P63522
GE59927
GE819180
GO:0003824
GO:0004421
GO:0005515
GO:0005737
GO:0005829
GO:0006084
GO:0006629
GO:0006695
GO:0006790
GO:0008299
GO:0010142
GO:0016740
GO:0016746
GO:0042803
GO:0055086
GO:1901135
HMNXSV003048724
Hs.77910.1.S1_3p_at
ILMN_1797728
L25798_at
TC05001316.hg
TC05002982.hg
g4504428_3p_a_at
Participates
as an output of
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
Inferred To
ERG13 [cytosol]
(Saccharomyces cerevisiae)
HMGCS1 [cytosol]
(Bos taurus)
HMGCS1 [cytosol]
(Canis familiaris)
HMGCS1 [cytosol]
(Drosophila melanogaster)
HMGCS1 [cytosol]
(Gallus gallus)
HMGCS1 [cytosol]
(Mus musculus)
HMGCS1 [cytosol]
(Rattus norvegicus)
HMGCS1 [cytosol]
(Sus scrofa)
hgsB [cytosol]
(Dictyostelium discoideum)
hcs1 [cytosol]
(Schizosaccharomyces pombe)
hmgs-1 [cytosol]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
638
ENSEMBL
ENSP00000322706
,
ENSP00000399402
,
ENST00000325110
,
ENST00000433297
OpenTargets
ENSG00000112972
HPA
ENSG00000112972-HMGCS1
PRO
Q01581
Pharos - Targets
Q01581
GlyGen
Q01581
HMDB Protein
HMDBP00053
PDB
2P8U
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76082 SLC22A5
7
SLC22A5 [plasma membrane]
(R-HSA-549319)
SLC22A5 W132* [plasma membrane]
(R-HSA-5625620)
SLC22A5 R169Q [plasma membrane]
(R-HSA-5625654)
SLC22A5 R169W [plasma membrane]
(R-HSA-5625686)
SLC22A5 R254* [plasma membrane]
(R-HSA-5625665)
SLC22A5 G15W [plasma membrane]
(R-HSA-5625680)
SLC22A5 P478L [plasma membrane]
(R-HSA-5625661)
0.564
2
UniProt:O60404 OR10H3
1
OR10H3 [endoplasmic reticulum membrane]
(R-HSA-9751545)
0.527
2
UniProt:P36952 SPB5
0.527
2
UniProt:O95221 OR5F1
1
OR5F1 [endoplasmic reticulum membrane]
(R-HSA-9751480)
0.527
2
UniProt:Q9BTV5 FSD1
0.527
2
UniProt:P18827 SDC1
20
HS(4)-SDC1 [plasma membrane]
(R-HSA-2076693)
HS(6)-SDC1 [plasma membrane]
(R-HSA-2076652)
HS(2)-SDC1 [plasma membrane]
(R-HSA-2076666)
HS(1)-SDC1 [plasma membrane]
(R-HSA-2076672)
HS(3)-SDC1 [plasma membrane]
(R-HSA-2076691)
HS(5)-SDC1 [plasma membrane]
(R-HSA-2076626)
SDC1 [plasma membrane]
(R-HSA-174758)
XylS-SDC1 [Golgi lumen]
(R-HSA-2064146)
Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064148)
SDC1 [Golgi lumen]
(R-HSA-2054105)
Gal-Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064247)
GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064082)
HS(3)-SDC1 [Golgi lumen]
(R-HSA-2076444)
HS(4)-SDC1 [Golgi lumen]
(R-HSA-2076593)
HS(2)-SDC1 [Golgi lumen]
(R-HSA-2076309)
HS(1)-SDC1 [Golgi lumen]
(R-HSA-2076321)
Heparan(4)-SDC1 [Golgi lumen]
(R-HSA-2076339)
Heparan(3)-SDC1 [Golgi lumen]
(R-HSA-2076314)
Heparan(2)-SDC1 [Golgi lumen]
(R-HSA-2076558)
Heparan(1)-SDC1 [Golgi lumen]
(R-HSA-2076349)
0.527
2
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
0.527
2
UniProt:Q15078 CDK5R1
4
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.527
2
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