Reduction of HMG-CoA produces mevalonate

Stable Identifier
R-HSA-191352
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the four-electron reduction of HMG-CoA to mevalonate. Mevalonate concentrations in the cell are tightly controlled through the activity of HMGR, which is one of the most highly regulated enzymes known (Goldstein and Brown 1990).

Literature References
PubMed ID Title Journal Year
10698924 Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

Istvan, ES, Palnitkar, M, Buchanan, SK, Deisenhofer, J

EMBO J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydroxymethylglutaryl-CoA reductase (NADPH) activity of HMGCR dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created